TPEN

ALX-450-011

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Heavy metal chelator

A cell permeable and extremely high-affinity chelator of heavy metals, yet with low affinity for Mg²⁺ and Ca²⁺. Lipid-soluble, crossing both natural and artificial membranes. TPEN can be used in conjunction with QUIN 2 (Prod. No. ENZ-52013) or QUIN 2/AM to reduce heavy-metal quenching of QUIN 2 fluorescence in cells. Ion specificity: Zn²⁺>Fe²⁺>Mn²⁺>>Ca²⁺=Mg²⁺. Complex with Fe²⁺ catalyzes superoxide dismutation. Induces DNA fragmentation when chelated with Zn²⁺ and induces apoptosis in T cells.

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Product Details

Alternative Name	N,N,N’,N’-Tetrakis-(2-pyridylmethyl)ethylenediamine
Appearance	White to light yellow to brown solid.
CAS	16858-02-9
Formula	C₂₆H₂₈N₆
MW	424.5
Purity	≥97% (Nonaqueous Titration)
Solubility	Soluble in dimethyl formamide, DMSO, 100% ethanol or methanol.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Defective Zn2+ homeostasis in mouse and human platelets with α- and δ-storage pool diseases: Kiran Gotru, S., van Geffen, J. P., et al.; Sci. Rep. 9, 8333 (2019), Abstract
Lysosomes shape Ins(1,4,5)P3-evoked Ca2+ signals by selectively sequestering Ca2+ released from the endoplasmic reticulum: López-Sanjurjo, C. I., Tovey, S. C., et al.; J. Cell Sci. 126, 289 (2013), Abstract
Depletion of Intracellular Zinc and Copper with TPEN Results in Apoptosis of Cultured Human Retinal Pigment Epithelial Cells: H.J. Hyun, et al.; Invest. Ophthalmol. Vis. Sci. 42, 460 (2001), Abstract
Cytotoxic actions of the heavy metal chelator TPEN on NG108-15 neuroblastoma-glioma cells: M. Adler, et al.; Neurotoxicology 20, 571 (1999), Abstract
The role of proteolysis in T cell apoptosis triggered by chelation of intracellular Zn2+: S. Jiang et al.; Cell Death Differ. 4, 39 (1997), Abstract
Chelation of intracellular zinc triggers apoptosis in mature thymocytes: M.J. McCabe, et al.; Lab. Invest. 69, 101 (1993), Abstract
TPEN, a transition metal chelator, improves myocardial protection during prolonged ischemia: M. Karck, et al.; J. Heart Lung Transplant 11, 979 (1992), Abstract
Mechanism of reaction of a suggested superoxide-dismutase mimic, Fe(II)- N,N,N’,N’-tetrakis(2-pyridylmethyl)ethylenediamine: L. Iuliano, et al.; Arch. Biochem. Biophys. 293, 153 (1992), Abstract
Measurement of intracellular cadmium with fluorescent dyes. Further evidence for the role of calcium channels in cadmium uptake [published erratum appears in J Biol Chem 1993 Mar 15;268(8):6064]: P.M. Hinkle, et al.; J. Biol. Chem. 267, 25553 (1992), Abstract — Full Text
Superoxide dismutase mimics based on iron in vivo: T. Nagano et al.; J. Biol. Chem. 264, 9243 (1989), Abstract

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TPEN

ALX-450-011

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