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Tosufloxacin . tosylate

ALX-380-303

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Fluoroquinolone antibacterial agent

Fluoroquinolone antibacterial agent. Inhibits bacterial DNA gyrase (topoisomerase). Effective against Gram-positive and Gram-negative aerobic bacteria, anaerobic bacteria and Chlamydia trachomatis.

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Product Details

Alternative Name	7-(3-Amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid . tosylate, A-64730
Appearance	White to yellow crystalline solid.
CAS	115964-29-9
Couple Target	DNA gyrase
Couple Type	Inhibitor
Formula	C₁₉H₁₅F₃N₄O₃ . C₇H₈O₃S
MI	14: 9555
MW	404.4 . 172.2
Purity	≥98% (HPLC)
Solubility	Slightly soluble in water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Tosufloxacin tosilate-induced thrombocytopenic purpura: H. Takahama & H. Tazaki; J. Dermatol. 34, 465 (2007), Abstract
Clinical assessment of tosufloxacin tosilate: S. Kohno; J. Infect. Chemother. 8, 19 (2002), (Review), Abstract
Antibacterial activities of tosufloxacin against anaerobic bacteria and the electron micrograph of its bactericidal effects: M. Takahata & T. Nishino; Chemotherapy 43, 153 (1997), Abstract
Stereoselective analysis of the disposition of tosufloxacin enantiomers in man: R. Minami, et al.; Eur. J. Clin. Pharmacol. 45, 489 (1993), Abstract
In-vitro activity of tosufloxacin, a new quinolone antibacterial agent: M.A. Cooper, et al.; J. Antimicrob. Chemother. 29, 639 (1992), Abstract
The in-vitro activity of tosufloxacin, a new fluorinated quinolone, compared with that of ciprofloxacin and temafloxacin: A. King, et al.; J. Antimicrob. Chemother. 28, 719 (1991), Abstract
In vitro activity of tosufloxacin, a new quinolone, against respiratory pathogens derived from cystic fibrosis sputum: A.G. Arguedas, et al.; Antimicrob. Agents Chemother. 34, 2223 (1990), Abstract — Full Text
Synthesis and biological properties of A-71497: a prodrug of tosufloxacin: D.T. Chu, et al.; Drugs Exp. Clin. Res. 16, 435 (1990), Abstract

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Tosufloxacin . tosylate

ALX-380-303

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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