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Topotecan . hydrochloride

ALX-350-133

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ALX-350-133-M001 — 1 mg

$48.00

Topotecan . hydrochloride quantity
ALX-350-133-M005 — 5 mg

$130.00

Topotecan . hydrochloride quantity
ALX-350-133-M025 — 25 mg

$501.00

Topotecan . hydrochloride quantity

Topoisomerase I inhibitor

Potent antitumor agent. Inhibitor of DNA-topoisomerase. Analog of (S)-(+)-camptothecin (Prod. No. ALX-350-015). Used in chemotherapy of several different cancers.

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Product Details

Alternative Name	9-[(Dimethylamino)methyl]-10-hydroxy-(20S)-camptothecin . HCl
Appearance	Light yellow to greenish powder.
CAS	119413-54-6
Couple Target	Topoisomerase
Couple Type	Inhibitor
Formula	C₂₃H₂₃N₃O₅ . HCl
MI	14: 9548
MW	458
Purity	≥98% (HPLC)
Solubility	Soluble in water (1mg/ml) or methanol.
Source	Semisynthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Division of Labor by the HELQ, BLM, and FANCM Helicases during Homologous Recombination Repair in Drosophila melanogaster: A. Thomas, et al.; Genes 13, 474 (2022), Abstract
Direct modification of the 5-HT3 receptor current by some anticancer drugs: Y. Nakamura, et al.; Eur. J. Pharmacol. 821, 21 (2017), Abstract
Common variants of Drosophila melanogaster Cyp6d2 cause camptothecin sensitivity and synergize with loss of Brca2: Thomas, A. M., Hui, C., et al.; G3 (Bethesda) 3, 91 (2013), Abstract
The geometry of DNA supercoils modulates the DNA cleavage activity of human topoisomerase I: Gentry, A. C., Juul, S., et al.; Nucleic Acids Res. 39, 1014 (2011), Abstract
Topotecan for the treatment of small-cell lung cancer: S.J. Nicum & M.E. O´Brien; Expert Rev. Anticancer Ther. 7, 795 (2007), Abstract
Topoisomerase I inhibition with topotecan: pharmacologic and clinical issues: B. Arun & E.P. Frenkel; Expert Opin. Pharmacother. 2, 491 (2001), Review, Abstract
Clinical status and optimal use of topotecan: C.H. Takimoto & S.G. Arbuck; Oncology (Williston Park) 11, 1635 (1997), Review, Abstract
In vitro and in vivo activity of topotecan against human B-lineage acute lymphoblastic leukemia cells: F.M. Uckun, et al.; Blood 85, 2817 (1995), Abstract
Synthesis of water-soluble (aminoalkyl)camptothecin analogues: inhibition of topoisomerase I and antitumor activity: W.D. Kingsbury, et al.; J. Med. Chem. 34, 98 (1991), Abstract

Related Products

(S)-(+)-Camptothecin

ALX-350-015

Potent antitumor agent

30 citations

CAS	7689-03-4
Couple Type	Activator, Inhibitor
Purity	≥98% (HPLC)

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Topotecan . hydrochloride

ALX-350-133

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