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BML-EI321

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Acetyl-CoA inhibitor

Hypolipidemic agent. Potent, reversible and competitive inhibitor of acetyl-coenzyme A carboxylase (Ac-CoA carboxylase; ACC), a key enzyme involved in fatty acid biosynthesis. It blocks apoptosis induced by the fatty acid synthase inhibitor C75 (Prod. No. ALX-270-286) and stimulates neurite outgrowth and neuronal differentiation in rat pheochromocytoma cells.

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Product Details

Alternative Name	5-(Tetradecyloxy)-2-furoic acid, RMI-14514
Appearance	Off-white solid.
CAS	54857-86-2
Couple Target	Acetyl-CoA
Couple Type	Inhibitor
Formula	C₁₉H₃₂O₄
MW	324.5
MeltingPoint	108-110°C
Purity	≥99% (TLC)
Solubility	Soluble in dimethyl formamide, DMSO (10mg/ml), 100% ethanol or methanol. Sparingly soluble in aqueous buffers.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Macrophage polarization state affects lipid composition and the channeling of exogenous fatty acids into endogenous lipid pools: P.K. Morgan, et al.; J. Biol. Chem. 297, 101341 (2021), Abstract
Mesothelioma tumor cells modulate dendritic cell lipid content, phenotype and function: J. K. Gardner, et al.; PLoS One 10, e0123563 (2015), Application(s): Cell Culture, Abstract — Full Text
C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism: L.E. Landree, et al.; J. Biol. Chem. 279, 3817 (2004), Abstract
Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells: W. Zhou, et al.; Cancer Res. 63, 7330 (2003), Abstract
Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors: T.M. Loftus, et al.; Science 288, 2379 (2000), Abstract
Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts: E.S. Pizer, et al.; Cancer Res. 60, 213 (2000), Abstract
Transcription control and neuronal differentiation by agents that activate the LXR nuclear receptor family: A. Schmidt, et al.; Mol. Cell. Endocrinol. 155, 51 (1999), Abstract
Inhibition of fatty acid synthesis decreases very low density lipoprotein secretion in the hamster: C.M. Arbeeny, et al.; J. Lipid Res. 33, 843 (1992), Abstract
Interactions between fatty acid synthesis, oxidation, and esterification in the production of triglyceride-rich lipoproteins by the liver: N. Fukuda and J.A. Ontko; J. Lipid Res. 25, 831 (1984), Abstract
Inhibition of fatty acid synthesis in isolated adipocytes by 5-(tetradecyloxy)-2-furoic acid: D.L. Halvorson & S.A. McCune; Lipids 19, 851 (1984), Abstract

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BML-EI321

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