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TNF-R1 (human):Fc (human), (recombinant)

ALX-522-013

8 citations

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TNF-R1 (human):Fc (human), (recombinant) image — **Figure**: Inhibition of TNF-mediated lysis of WEHI 164 target cells (rhsTNF-a, Prod. No. ALX-522-008). rhTNF-R1:Fc exerts its inhibitory activity in a concentration range of 10-50ng/ml.”””,TNF-R1 (human):Fc (human)

Product Details

Alternative Name	p55, CD120a, TNF-R 60kDa, TNFRSF 1A
Application Notes	ELISA: binds to TNF-α.
Concentration	1mg/ml after reconstitution.
Endotoxin Content	<0.1EU/µg purified protein (LAL test; Bio Whittaker).
Formulation	Lyophilized. Contains PBS.
MW	~60kDa (reducing SDS-PAGE).
Purity	≥95% (SDS-PAGE)
Reconstitution	Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or carrier protein.
Source	Produced in HEK 293 cells. The extracellular domain of human TNF-R1 (aa 1-211) is fused to the Fc portion of human IgG1.
Specificity	Binds human and mouse TNF-α (tumor necrosis factor-a).
Technical Info / Product Notes	Previous data has shown that TNF-R1 receptor binds to TNF-R1 and triggers various biological effects (including cell death). rhTNF-R1:Fc fusion protein blocks TNF-α-mediated lysis with a inhibitory activity in a concentration range of 10-50ng/ml using Wehi cells.
UniProt ID	P19438

Handling & Storage

Use/Stability	Stable for at least 6 months after receipt when stored at -20°C.
Handling	Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Proteasome inhibition triggers the formation of TRAIL receptor 2 platforms for caspase-8 activation that accumulate in the cytosol: C.T. Hellwig, et al.; Cell Death Differ. 29, 147 (2022), Abstract
Sensing plasma membrane pore formation induces chemokine production in survivors of regulated necrosis: Wang, W., Prokopec, J. S., et al.; Dev. Cell 57, 228 (2022), Abstract
Small-Molecule Inhibitors of the Coronavirus Spike: ACE2 Protein-Protein Interaction as Blockers of Viral Attachment and Entry for SARS-CoV-2: Bojadzic, D., Alcazar, O., et al.; ACS Infect. Dis. 7, 1519 (2021), Abstract
Small-Molecule i>In Vitro/i> Inhibitors of the Coronavirus Spike – ACE2 Protein-Protein Interaction as Blockers of Viral Attachment and Entry for SARS-CoV-2: Bojadzic, D., Alcazar, O., et al.; bioRxiv , (2020)
TNF-α and IFN-γ are potential inducers of Fas-mediated keratinocyte apoptosis through activation of inducible nitric oxide synthase in toxic epidermal necrolysis: I. Viard-Leveugle, et al.; J. Invest. Dermatol. 133, 489 (2013), Application(s): Flow cytometry analysis of NO production in mammalian cells, Abstract
Proteasome inhibition can induce an autophagy-dependent apical activation of caspase-8: M.A. Laussmann, et al.; Cell Death Differ. 18, 1584 (2011), Abstract
The lymphotoxin-β receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells: I.A. Rooney, et al.; J. Biol. Chem. 275, 13047 (2000), Abstract — Full Text
Development of improved soluble inhibitors of FasL and CD40L based on oligomerized receptors: N. Holler, et al.; J. Immunol. Methods 237, 159 (2000), Abstract

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Alternative Name	Thy-1 (RLE mutant)
Purity	≥90% (SDS-PAGE)
Source	Produced in HEK 293 cells. The extracellular domain of mutated hThy-1, hThy-1 (RLE) (aa 20-130), is fused to the Fc portion of human IgG1. The integrin binding sequence RLD of hThy-1 has been changed to RLE abolishing the binding of integrins.

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TNF-R1 (human):Fc (human), (recombinant)

ALX-522-013

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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