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This antibody is covered by our Worry-Free Guarantee.
Product Details
| Alternative Name |
TNF-R 60kDa, CD120a, p55, TNFRSF 1A |
|---|---|
| Application |
Flow Cytometry, FUNC, IHC (FS) |
| Application Notes |
Not recommended for IHC (PS). |
| Clone |
H398 |
| Crossreactivity |
Does not cross-react with mouse TNF-R1. |
| Formulation |
Liquid. In PBS. |
| Host |
Mouse |
| Immunogen |
Human TNF-R1. |
| Isotype |
IgG2a |
| Purity Detail |
Protein G affinity purified. |
| Recommendation Dilutions/Conditions |
Immunohistochemistry (frozen sections; stains acetone-fixed cryostat sections or cell smears. Recommended for H398 is the alkaline phosphatase-anti-alkaline-phosphatase (APAAP)or peroxidase anti-peroxidase (PAP) procedures or the three stage immunoperoxidase technique on acetone-fixed cryostat sections. H398 may be used at a concentration of 1-0.5mg/ml for cryostat sections)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. |
| Species Reactivity |
Human |
| Specificity |
Recognizes membrane-bound and soluble TNF-R1. |
| UniProt ID |
P19438 |
| Worry-free Guarantee |
This antibody is covered by our Worry-Free Guarantee. |
Handling & Storage
| Handling |
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C. |
|---|---|
| Long Term Storage |
+4°C |
| Shipping |
Blue Ice |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Epigenetically Enhanced PDT Induces Significantly Higher Levels of Multiple Extrinsic Pathway Apoptotic Factors than Standard PDT, Resulting in Greater Extrinsic and Overall Apoptosis of Cutaneous T-cell Lymphoma: Salva, K. A., Kim, Y. H., et al.; Photochem. Photobiol. 94, 1058 (2018), Abstract
- TNFalpha-induced GM-CSF release from human airway smooth muscle cells depends on activation of an ET-1 autoregulatory positive feedback mechanism.: Müller, K., Koch, A., et al.; Thorax 64, 1044 (2009), Reactant(s): Human, Abstract
- Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy: C. Gajate & F. Mollinedo; J. Biol. Chem. 280, 11641 (2005), Abstract — Full Text
- Innate direct anticancer effector function of human immature dendritic cells. II. Role of TNF, lymphotoxin-alpha(1)beta(2), Fas ligand, and TNF-related apoptosis-inducing ligand: G. Lu, et al.; J. Immunol. 168, 1831 (2002), Abstract
- Interferon-gamma rescues TNF-alpha-induced apoptosis mediated by up-regulation of TNFR2 on EoL-1 cells: T. Horie, et al.; Exp. Hematol. 27, 512 (1999), Abstract
- Cycloheximide-induced T-cell death is mediated by a Fas-associated death domain-dependent mechanism: D. Tang, et al.; J. Biol. Chem. 274, 7245 (1999), Abstract — Full Text
- Lipopolysaccharide mediates endothelial apoptosis by a FADD-dependent pathway: K.B. Choi, et al.; J. Biol. Chem. 273, 20185 (1998), Abstract — Full Text
- 1alpha,25-dihydroxyvitamin D3 induces sphingomyelin hydrolysis in HaCaT cells via tumor necrosis factor alpha: C.C. Geilen, et al.; J. Biol. Chem. 272, 8997 (1997), Abstract — Full Text
- Gastrin secretion from primary cultures of rabbit antral G cells: stimulation by inflammatory cytokines: N. Weigert, et al.; Gastroenterology 110, 147 (1996), Abstract
- TNF-induced superoxide anion production in adherent human neutrophils involves both the p55 and p75 TNF receptor: J. Richter, et al.; J. Immunol. 154, 4142 (1995), Abstract
- Lymphotoxin acts as an autocrine growth factor for Epstein-Barr virus-transformed B cells and differentiated Burkitt lymphoma cell lines: D.L. Gibbons, et al.; Eur. J. Immunol. 24, 1879 (1994), Abstract
- Cytostatic and cytotoxic effects of tumor necrosis factor alpha on MCF-7 human breast tumor cells are differently inhibited by glucocorticoid hormones: M.C. Pagliacci, et al.; Lymphokine Cytokine Res. 12, 439 (1993), Abstract
- TR60 and TR80 tumor necrosis factor (TNF)-receptors can independently mediate cytolysis: M. Grell, et al.; Lymphokine Cytokine Res. 12, 143 (1993), Abstract
- Inhibition of tumor necrosis factor (TNF)-mediated NF-kappa B activation by selective blockade of the human 55-kDa TNF receptor: G. Kruppa, et al.; J. Immunol. 148, 3152 (1992), Abstract
- Monoclonal antibodies to soluble human TNF receptor (TNF binding protein) enhance its ability to block TNF toxicity: G.R. Adolf & B. Fruhbeis; Cytokine 4, 180 (1992), Abstract
- Identification of a 60-kD tumor necrosis factor (TNF) receptor as the major signal transducing component in TNF responses: B. Thoma, et al.; J. Exp. Med. 172, 1019 (1990), Abstract
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