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TMRE (ultra pure)

ENZ-52309

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Mitochondria dye

Positively charged rhodamine dyes (such as rhodamine esters and rosamines) are selectively localized in mitochondria, thus they are widely used for labeling mitochondria of live cells. Like JC-1,TMRE is widely used for measuring mitochondrial membrane potential, in addition to selectively staining mitochondria. Real-time imaging of mitochondrial membrane potential in individual cardiomyocytes within perfused rat hearts has been demonstrated with this dye, using 2-photon laser-scanning microscopy. Wavelength Maxima: Excitation 549nm, Emission 574nm

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Product Details

Alternative Name	Tetramethylrhodamine ethyl ester perchlorate, 3,6-bis(Dimethylamino)-9-[2-(ethoxycarbonyl)phenyl]-xanthylium perchlorate
CAS	115532-52-0
Formula	C₂₆H₂₇ClN₂O₇
MW	515.0
Purity	≥95% (HPLC)
Solubility	Soluble in DMSO.
Technical Info / Product Notes	This product is a member of the CELLESTIAL^® product line, reagents and assay kits comprising fluorescent molecular probes that have been extensively benchmarked for live cell analysis applications. CELLESTIAL^® reagents and kits are optimal for use in demanding imaging applications, such as confocal microscopy, flow cytometry and HCS, where consistency and reproducibility are required.

Handling & Storage

Use/Stability	Stable for at least one year after receipt when stored as recommended.
Handling	Protect from light. Keep cool and dry.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

A visualized and quercetin-optimized three-dimensional culture model of mouse ovaries derived from fetal gonads: Cui, M., Zheng, Z., et al.; Acta Biochim. Biophys. Sin. (Shanghai) , (2025), Abstract
Alternative splicing expands the clinical spectrum of NDUFS6-related mitochondrial disorders: Armirola-Ricaurte, C., Zonnekein, N., et al.; Genet. Med. 26, 101117 (2024), Abstract
Autophagy regulates the maturation of hematopoietic precursors in the embryo: Liu, Y., Shi, L., et al.; Nat. Commun. 15, 2255 (2024), Abstract
Autophagy counters inflammation-driven glycolytic impairment in aging hematopoietic stem cells: Dellorusso, P. V., Proven, M. A., et al.; Cell Stem Cell 31, 1020 (2024), Abstract
Small heat shock proteins operate as molecular chaperones in the mitochondrial intermembrane space: Adriaenssens, E., Asselbergh, B., et al.; Nat. Cell Biol. 25, 467 (2023), Abstract
The glyoxylate shunt protein ICL-1 protects from mitochondrial superoxide stress through activation of the mitochondrial unfolded protein response: Wang, G., Laranjeiro, R., et al.; Free Radic. Biol. Med. 208, 771 (2023), Abstract
Heterozygous variants in CTR9, which encodes a major component of the PAF1 complex, are associated with a neurodevelopmental disorder: Meuwissen, M., Verstraeten, A., et al.; Genet. Med. 24, 1583 (2022), Abstract
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions: Ho, T. T., Dellorusso, P. V., et al.; J. Exp. Med. 218, (2021), Abstract
PUMILIO hyperactivity drives premature aging of Norad-deficient mice: F. Kopp, et al.; Elife 8, e42650 (2019), Application(s): Flow cytometry using immortalized MEFs, Abstract — Full Text
Role of Mitochondria in Ferroptosis: Gao, M., Yi, J., et al.; Mol. Cell 73, 354 (2019), Abstract

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TMRE (ultra pure)

ENZ-52309

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Handling & Storage

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