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PARP-1 inhibitor

Potent poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor (IC₅₀=450nM). Neuroprotectant.

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Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Novel isoquinolinone-derived inhibitors of poly(ADP-ribose) polymerase-1: pharmacological characterization and neuroprotective effects in an in vitro model of cerebral ischemia: A. Chiarugi, et al.; J. Pharmacol. Exp. Ther. 305, 943 (2003), Abstract — Full Text
Towards new neuroprotective agents: design and synthesis of 4H-thieno[2,3-c] isoquinolin-5-one derivatives as potent PARP-1 inhibitors: R. Pellicciari, et al.; Farmaco 58, 851 (2003), Abstract

Last modified: May 29, 2024

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