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Tin Protoporphyrin IX . dichloride

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Heme oxygenase inhibitor

Potent inhibitor of heme oxygenase.

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Appearance	Dark red to violet solid.
CAS	14325-05-4
Couple Target	Heme oxygenase
Couple Type	Inhibitor
Formula	C₃₄H₃₂N₄O₄Sn . 2Cl
Identity	Identity determined by NMR and UV VIS.
MW	750.3
Purity	≥95% (HPLC)
Solubility	Soluble in aqueous base.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

A Thia-Analogous Indirubin N-Glycoside Disrupts Mitochondrial Function and Causes the Death of Human Melanoma and Cutaneous Squamous Cell Carcinoma Cells: Wendt, F., Wittig, F., et al.; Cells 12, (2023), Abstract
Heme oxygenase-1 in the spinal cord plays crucial roles in the analgesic effects of pregabalin and gabapentin in a spared nerve-injury mouse model: K. Godai, et al.; Neurosci. Lett. 767, 136310 (2022), Abstract
GM-CSF-mediated inducement of bone marrow MDSCs by TSA and effect on survival of graft in mice: S. Zhao, et al.; Eur. J. Med. Res. 27, 161 (2022), Abstract
The Combination of Δ9-Tetrahydrocannabinol and Cannabidiol Suppresses Mitochondrial Respiration of Human Glioblastoma Cells via Downregulation of Specific Respiratory Chain Proteins: Rupprecht, A., Theisen, U., et al.; Cancers (Basel) 14, (2022), Abstract
Cepharanthine mitigates lung injury in lower limb ischemia–reperfusion: M.C. Kao, et al.; J. Surg. Res. 199, 647 (2015), Application(s): Injection into rat, Abstract
Cepharanthine mitigates pro-inflammatory cytokine response in lung injury induced by hemorrhagic shock/resuscitation in rats: M.C. Kao, et al.; Cytokine 76, 442 (2015), Application(s): Injection into rat, Abstract
Prevention of neonatal hyperbilirubinemia by tin protoporphyrin IX, a potent competitive inhibitor of heme oxidation: G.S. Drummond & A. Kappas; PNAS 78, 6466 (1981), Abstract

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