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The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. It is expressed on several classes of T cells including follicular B helper T cells (TFH). TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses. TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer. Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer.
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Flow cytometry analysis of TIGIT over expressing HEK293 cells using TIGIT antibody at 1 µg/ml. Blue: untransfected HEK293 cells. Yellow: TIGIT over expressing HEK293 cells.
Immunocytochemistry of TIGIT in over expressing HEK293 cells using TIGIT antibody and control mouse IgG antibody (left corner box) at 1 µg/ml.
Immunofluorescence of TIGIT in over expressing HEK293 cells using TIGIT Antibody at 1 µg/ml.
Green: TIGIT Antibody [4A12]
Blue: DAPI staining
Western blot analysis of TIGIT in over expressing HEK293 cells using ENZ-ABS698 antibody at (A) 0.25 µg/ml , (B) 0.5 ug/ml, and (C) 1 µg/ml.
Immunohistochemistry of TIGIT in human stomach carcinoma tissue using TIGIT Antibody and control mouse IgG (corner box) at 2 µg/ml.
| Regulatory Status |
RUO – Research Use Only |
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