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Thrombin (human plasma), (purified)

BML-SE363

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Thrombin (factor IIa) is a serine endopeptidase comprising a light and a heavy chain, the latter being the catalytic subunit. Thrombin is a necessary component of the clotting cascade, and is important in cardiovascular research and drug development, and may play a role in Alzheimer’s disease as well.

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Product Details

MW	37 kDa
Source	The human Thrombin was activated from homogeneous human prothrombin by activation with Factor Xa, Factor Va, and phospholipid. These activation enzymes were removed after activation. Complete activation was observed on SDS-PAGE. The above protein was purified from Human plasma units that test negative for antibodies to HBc, HCV, HIV 1/2, HTLV-I/II, and non-reactive for HBsAg, HIV-1 RNA, HCV RNA, HBV DNA and Syphilis by FDA approved tests. Donors are screened for CJD.
UniProt ID	P00734

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Significance of FXa and its receptor PAR2 for the growth of colon cancer cells in vitro and in vivo: Meyer, U., Rönnpagel, V., et al.; Front. Oncol. 15, 1631350 (2025), Abstract
Interface Engineering of “Clickable” Organic Electrochemical Transistors toward Biosensing Devices: G.E. Fenoy, et al.; ACS Appl. Mater. Interfaces 15, 10885 (2023), Abstract
Release of platelet-derived sphingosine-1-phosphate involves multidrug resistance protein 4 (MRP4/ABCC4) and is inhibited by statins: K. Vogt, et al.; Thromb. Haemost. 118, 132 (2018), Abstract
Multiple modes of capillary electrophoresis applied in peptide nucleic acid related study: X. Wang, et al.; J. Chromatogr. A. 1501, 161 (2017), Abstract

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Thrombin (human plasma), (purified)

BML-SE363

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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