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Thioetheramide-phosphorylcholine

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Phospholipase inhibitor

A potent substrate analog inhibitor of snake venom PLA₂ (IC₅₀=2 µM). It inhibits human recombinant sPLA₂ (IC₅₀=0.9 µM) selectively over cPLA₂.

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Alternative Name	1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine
Appearance	White solid.
CAS	116457-99-9
Couple Target	Phospholipase, PLA
Couple Type	Inhibitor
Formula	C₄₀H₈₃N₂O₅PS
MW	735.6
Purity	≥98% (TLC)
Solubility	Soluble in DMSO, 100% ethanol or methanol.

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Handling	Protect from moisture.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Secretory phospholipase A2 inhibitors and calmodulin antagonists as inhibitors of cytosolic phospholipase A2: W.C. Hope, et al.; Agents Actions 39, C39 (1993), Abstract
The interaction of phospholipase A2 with phospholipid analogues and inhibitors: L. Yu, et al.; J. Biol. Chem. 265, 2657 (1990), Abstract

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