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Thimerosal

ALX-400-013

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Antiseptic and antifungal agent

Modulates thiol groups in biological systems, especially in those involving cAMP, Ca2+ and inositol phosphate. Causes a release of calcium from intracellular stores in many cells types. Has toxic effects on several cell types. Induces apoptosis in vitro.

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Product Details

Alternative Name	Ethyl mercurithiosalicylic acid . Na, Mercurothiolate
Appearance	White to off-white powder.
CAS	54-64-8
Formula	C₉H₉HgO₂SNa
MI	14: 9317
MW	404.8
Purity	≥98% (HPLC)
Solubility	Soluble in water (600mg/ml) or methanol.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

CPO Complete, a novel test for fast, accurate phenotypic detection and classification of carbapenemases: Thomson, G. K., AbdelGhani, S., et al.; PLoS One 14, e0220586 (2019), Abstract
Regulation of synaptic nlg-1/neuroligin abundance by the skn-1/Nrf stress response pathway protects against oxidative stress: Staab, T. A., Evgrafov, O., et al.; PLoS Genet. 10, e1004100 (2014), Abstract
Being on the track of thimerosal: A. Madi; Acta Microbiol. Immunol. Hung. 52, 95 (2005), Abstract
Thimerosal stimulates Ca2+ flux through inositol 1,4,5-trisphosphate receptor type 1, but not type 3, via modulation of an isoform-specific Ca2+-dependent intramolecular interaction: G. Bultynck, et al.; Biochem. J. 381, 87 (2004), Abstract
Thimerosal induces DNA breaks, caspase-3 activation, membrane damage, and cell death in cultured human neurons and fibroblasts: D. S. Baskin, et al.; Toxicol. Sci. 74, 361 (2003), Abstract
Thimerosal: a versatile sulfhydryl reagent, calcium mobilizer, and cell function-modulating agent:: J.G. Elferink; Gen. Pharmacol. 33, 1 (1999), (Review), Abstract
The effects of thimerosal on calcium uptake and inositol 1,4,5- trisphosphate-induced calcium release in cerebellar microsomes: L.G. Sayers, et al.; Biochem. J. 289, 883 (1993), Abstract
Antibody to the inositol trisphosphate receptor blocks thimerosal- enhanced Ca(2+)-induced Ca2+ release and Ca2+ oscillations in hamster eggs: S. Miyazaki, et al.; FEBS Lett. 309, 180 (1992), Abstract
Thimerosal causes calcium oscillations and sensitizes calcium-induced calcium release in unfertilized hamster eggs: K. Swann; FEBS Lett. 278, 175 (1991), Abstract
Disulfide linkage of biotin identifies a 106-kDa Ca2+ release channel in sarcoplasmic reticulum: N.F. Zaidi, et al.; J. Biol. Chem. 264, 21737 (1989), Abstract — Full Text

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Thimerosal

ALX-400-013

Product Details

Handling & Storage

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