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Thalidomide, conjugating enzyme inhibitor

LSI-SI-9820

Axxora Marketplace
  • LSI-SI-9820-0100   —   100 mg
    $179.00
  • LSI-SI-9820-0200   —   200 mg
    $314.00

Thalidomide binds to the E3 ubiquitin ligase complex formed between cereblon (CRBN), damaged DNA binding protein 1 (DDB1), and Cul4A inhibiting ligase activity. Inhibits TNF synthesis and FGF-induced angiogenesis. Thalidomide initiates its teratogenic effects by binding to CRBN and inhibiting the associated ubiquitin E3 ligase activity. Cell permeable. Caution: Teratogenic.

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Regulatory Status

RUO – Research Use Only