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Na+ channel blocker
Tetrodotoxin is a non-peptide toxin isolated from ovaries and liver of Chinese puffer fish. Neurotoxin. Potent and reversible inhibitor of the voltage dependent Na+ channels in nerve membranes.
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Product Details
| Alternative Name |
TTX, Fugu poison |
|---|---|
| Appearance |
White to off-white solid. |
| CAS |
4368-28-9 |
| Couple Target |
Sodium channel |
| Couple Type |
Blocker |
| Formula |
C11H17N3O8 |
| MI |
14: 9246 |
| MW |
319.3 |
| Purity |
≥98% (HPLC) |
| RTECS |
IO1450000 |
| Solubility |
Soluble in dilute acetic acid (e.g. 1mg/ml in 10mM HOAc or 10mg/ml in 0.1M HOAc) or in citric acid/sodium citrate buffer, pH 4.8 (e.g. 1mg/ml in 20mM buffer). Do not use alkaline solution. |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
|---|---|
| Handling |
Avoid strongly acidic or alkaline solutions. USE EXTREME CAUTION! MAY CAUSE DEATH. |
| Short Term Storage |
-20°C |
| Long Term Storage |
-20°C |
| Shipping |
Ambient Temperature |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Chronic modulation of cAMP signaling elicits synaptic scaling irrespective of activity: Bagatelas, E. D., Kavalali, E. T., et al.; iScience 27, 110176 (2024), Abstract
- Neurotransmitter release progressively desynchronizes in induced human neurons during synapse maturation and aging: Uzay, B., Houcek, A., et al.; Cell Rep. 42, 112042 (2023), Abstract
- Presynaptic mechanisms underlying GABAB-receptor-mediated inhibition of spontaneous neurotransmitter release: B. Alten, et al.; Cell Rep. 38, 110255 (2022), Abstract
- Nano-organization of spontaneous GABAergic transmission directs its autonomous function in neuronal signaling: N.J. Guzikowski & E.T. Kavalali; Cell Rep. 40, 111172 (2022), Abstract
- Probing the segregation of evoked and spontaneous neurotransmission via photobleaching and recovery of a fluorescent glutamate sensor: Wang, C. S., Chanaday, N. L., et al.; Elife 11, (2022), Abstract
- Role of Aberrant Spontaneous Neurotransmission in SNAP25-Associated Encephalopathies: Alten, B., Zhou, Q., et al.; Neuron 109, 59 (2021), Abstract
- A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strength: P.M. Horvath, et al.; Cell Rep. 36, 109467 (2021), Abstract
- RNA editing-mediated regulation of calcium-dependent activator protein for secretion (CAPS1) localization and its impact on synaptic transmission: Shumate, K. M., Tas, S. T., et al.; J. Neurochem. 158, 182 (2021), Abstract
- Presynaptic store-operated Ca2+ entry drives excitatory spontaneous neurotransmission and augments endoplasmic reticulum stress: Chanaday, N. L., Nosyreva, E., et al.; Neuron 109, 1314 (2021), Abstract
- Interneuronal exchange and functional integration of synaptobrevin via extracellular vesicles: Vilcaes, A. A., Chanaday, N. L., et al.; Neuron 109, 971 (2021), Abstract
- Convergence of distinct signaling pathways on synaptic scaling to trigger rapid antidepressant action: K. Suzuki, et al.; Cell Rep. 37, 109918 (2021), Abstract
- A Neural Network for Wind-Guided Compass Navigation: Okubo, T. S., Patella, P., et al.; Neuron 107, 924 (2020), Abstract
- Genetic inactivation of mTORC1 or mTORC2 in neurons reveals distinct functions in glutamatergic synaptic transmission: M.P. McCabe, et al.; Elife 9, e51440 (2020), Abstract
- Intrinsic neuronal properties represent song and error in zebra finch vocal learning: Daou, A., Margoliash, D., et al.; Nat. Commun. 11, 952 (2020), Abstract
- Voltage-gated potassium channels are critical for infrared inhibition of action potentials: an experimental study: M. Ganguly, et al.; Neurophotonics 6, 40501 (2019), Abstract — Full Text
- Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors: T. Chernov-Rogan, et al.; PNAS 115, E792 (2018), Abstract — Full Text
- Calcimimetic R568 inhibits tetrodotoxin-sensitive colonic electrolyte secretion and reduces c-fos expression in myenteric neurons: X. Sun, et al.; Life Sci. 194, 49 (2018), Abstract
- Optical detection of three modes of endocytosis at hippocampal synapses: Chanaday, N. L., Kavalali, E. T., et al.; Elife 7, (2018), Abstract
- Upregulation of Voltage-Gated Calcium Channel Cav1.3 in Bovine Somatotropes Treated with Ghrelin: V.M. Salinas Zarate, et al.; J. Signal Transduct. 2013, 527253 (2013), Abstract — Full Text
- Calcium-sensing receptor inhibits secretagogue-induced electrolyte secretion by intestine via the enteric nervous system: S.X. Cheng; Am. J. Physiol. Gastrointest. Liver Physiol. 303, G60 (2012), Abstract
- Tetrodotoxin poisoning: D.F. Hwang & T. Noguchi; Adv. Food Nutr. Res. 52, 141 (2007), Abstract
- Recent advances in the study of mechanism of action of marine neurotoxins: T. Narahashi, et al.; Neurotoxicology 15, 545 (1994), Abstract
- Functional properties of rat brain sodium channels expressed in a somatic cell line: T. Scheuer, et al.; Science 247, 854 (1990), Abstract
- Structure and function of voltage-sensitive ion channels: W.A. Catterall; Science 242, 50 (1988), Abstract
- Molecular properties of voltage-sensitive sodium channels: W.A. Catterall; Annu. Rev. Biochem. 55, 953 (1986), Abstract
- Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes: W.A. Catterall; Annu. Rev. Pharmacol. Toxicol. 20, 15 (1980), Abstract
- The constituents of the ovaries of globefish. VIII. Studies on tetrodotoxin: K. Tsuda & M. Kawamura; Pharm. Bull. 1, 112 (1953), Abstract
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