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Terbinafine HCl

BML-EI318

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Squalene epoxidase inhibitor

Inhibits ergosterol biosynthesis at the level of squalene epoxidase. Potent non-competitive inhibitor of squalene epoxidase from Candida (K_i=30 nM), inhibiting mammalian enzymes at higher concentrations (4-77 µM). It inhibits HUVEC proliferation and angiogenesis and displays interesting anti-inflammatory and free radical scavenging activities. Clinically useful antifungal agent.

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Product Details

Alternative Name	trans-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthylmethylamine . hydrochloride
Appearance	White to off-white solid.
CAS	78628-80-5
Couple Target	Squalene epoxidase
Couple Type	Inhibitor
Formula	C₂₁H₂₅N . HCl
MW	327.9
Purity	≥98% (UHPLC)
Solubility	Soluble in ethanol (45 mg/ml), DMSO (30 mg/ml) or water (3 mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Inhibition of human vascular endothelial cells proliferation by terbinafine: P. Y. Ho, et al.; Int. J. Cancer 111, 51 (2004), Abstract
Inhibitory effect of terbinafine on reactive oxygen species (ROS) generation by Candida albicans: C. S. Sander, et al.; Mycoses 45, 152 (2002), Abstract
Differential inhibition of fungal amd mammalian squalene epoxidases by the benzylamine SDZ SBA 586 in comparison with the allylamine terbinafine: B. Favre, et al.; Arch. Biochem. Biophys. 340, 265 (1997), Abstract
Anti-inflammatory activity of antifungal preparations: T. Rosen, et al.; Int. J. Dermatol. 36, 788 (1997), Abstract
Terbinafine: mode of action and properties of the squalene epoxidase inhibition: N. S. Ryder, et al.; Br. J. Dermatol. 126, 39 (1992), Abstract

Last modified: May 29, 2024

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Terbinafine HCl

BML-EI318

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