Tentoxin

ALX-350-132

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F-ATPase inhibitor

Cyclic tetrapeptide. Inhibitor of chloroplast F₁-ATPase (CF₁). Does not inhibit the homologous enzymes from chloroplasts of insusceptible plant species or from bacteria or mitochondria.

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Product Details

Alternative Name	cyclo-(N-Methyl-L-alanyl-L-leucyl-N-methyl-(Z)-dihydrophenylalanyl-glycyl)
Appearance	Off-white to yellow powder.
CAS	28540-82-1
Couple Target	ATPase
Couple Type	Inhibitor
Formula	C₂₂H₃₀N₄O₄
MW	414.5
Purity	≥98% (HPLC, TLC)
Purity Detail	Free of any peptide contaminations, especially dihydrotentoxin.
Solubility	Soluble in DMSO (10mg/ml) or methanol (10mg/ml).
Source	Isolated from Alternaria alternata.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Dual effectiveness of Alternaria but not Fusarium mycotoxins against human topoisomerase II and bacterial gyrase: Arch. Toxicol.; J. Kim, et al. 91, 2007 (2017), Application(s): Impact on the activity of human and bacterial topo II., Abstract
Complete inhibition and partial Re-activation of single F1-ATPase molecules by tentoxin: new properties of the re-activated enzyme: P. Pavlova, et al.; J. Biol. Chem. 279, 9685 (2004), Abstract — Full Text
Metabolism of tentoxin by hepatic cytochrome P-450 3A isozymes: M. Delaforge, et al.; Eur. J. Biochem. 250, 150 (1997), Abstract
Effects of tentoxin and dihydrotentoxin on human erythrocytes: K. Gwozdzinski, et al.; Cytobios. 67, 183 (1991), Abstract

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Tentoxin

ALX-350-132

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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