Home Shop Teniposide

Teniposide

Already have an account?

Topoisomerase II inhibitor

Glycoside-derivative of podophyllotoxin. Has cytostatic effect. Inhibits topoisomerase II. Induces apoptosis.

Shipping: Available products typically ship within 24/48h, via priority shipping.

Do you need support? Contact Customer Service or Technical Support.

Online Account
Access or Create Your Account

Alternative Name	(5R,5aR,8aR,9S)-5,8,8a,9-Tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-[(R)-2-thienylmethylene]-β-D-glucopyranosyl]oxy]furo[3’,4’:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 4’-Demethylepipodophyllotoxin-β-D-thenylidine glucoside
Appearance	White to off-white powder.
CAS	29767-20-2
Couple Target	Topoisomerase
Couple Type	Inhibitor
Formula	C₃₂H₃₂O₁₃S
Identity	Determined by IR.
MI	14: 9145
MW	656.7
Purity	≥97% (HPLC)
Solubility	Soluble in acetone or dimethyl formamide; slightly soluble in methanol; insoluble in water.
Source	Semisynthetic derivative of podophyllotoxin.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Regulation of hepatic cholesteryl ester transfer protein expression and reverse cholesterol transport by inhibition of DNA topoisomerase II: M. Liu, et al.; J. Biol. Chem. 290, 14418 (2015), Application(s): Cell Culture, Injection into mice, Abstract — Full Text
Natural compounds with P2X7 receptor-modulating properties: Fischer, W., Urban, N., et al.; Purinergic Signal. 10, 313 (2013), Abstract
Topoisomerase II trapping agent teniposide induces apoptosis and G2/M or S phase arrest of oral squamous cell carcinoma: J. Li, et al.; World J. Surg. Oncol. 4, 41 (2006), Abstract — Full Text
Topoisomerase II as a target of VM-26 and 4’-(9-acridinylamino)methanesulfon-m-aniside in atypical multidrug resistant human small cell lung carcinoma cells: S. de Jong, et al.; Cancer Res. 53, 1064 (1993), Abstract — Full Text
Human cytochrome P450 metabolism of teniposide and etoposide: M.V. Relling, et al.; J. Pharmacol. Exp. Ther. 261, 491 (1992), Abstract
Role of topoisomerase II in mediating epipodophyllotoxin-induced DNA cleavage: W. Ross, et al.; Cancer Res. 44, 5857 (1984), Abstract — Full Text

Related Products

Topoisomerase inhibitor

Please enter the lot number as featured on the product label

Lot No. :

Enzo Life Science provides GHS Compliant SDS

If your language is not available please fill out the SDS request form