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SOD mimetic
Small molecule cell-permeable superoxide dismutase (SOD) mimetic. It attenuates superoxide anion and peroxynitrite-induced inflammation, lowers blood peressure in a variety of models and displays neuroprotective effects. It restores mitochondrial and cardiac functions in TNFα-induced oxidative stress and reduces cardiac hypertrophy in chronic hypoxic rats.
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Product Details
| Alternative Name |
4-OH-TEMPO, 4-Hydroxy-TEMPO, 4-Hydroxy-2,2,6,6-tetramethylpiperidinyloxy, free radical |
|---|---|
| Appearance |
Yellow to orange crystalline solid. |
| CAS |
2226-96-2 |
| Formula |
C9H18NO2 |
| MW |
172.2 |
| Purity |
≥98% (HPLC) |
| Solubility |
Soluble in water, 100% ethanol, methanol or DMSO. |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. |
|---|---|
| Handling |
Protect from light. |
| Long Term Storage |
-20°C |
| Shipping |
Blue Ice |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Protein adduction causes non-mutational inhibition of p53 tumor suppressor: Caspa Gokulan, R., Paulrasu, K., et al.; Cell Rep. 42, 112024 (2023), Abstract
- Aristolochic acid I induces proximal tubule injury through ROS/HMGB1/mt DNA mediated activation of TLRs: R. Upadhyay, et al.; J. Cell. Mol. Med. 26, 4277 (2022), Abstract
- Selective deficiency in endothelial PTP1B protects from diabetes and endoplasmic reticulum stress-associated endothelial dysfunction via preventing endothelial cell apoptosis: Legeay, S., Fautrat, P., et al.; Biomed. Pharmacother. 127, 110200 (2020), Abstract
- A comprehensive evaluation of catalase-like activity of different classes of redox-active therapeutics: Tovmasyan, A., Maia, C. G., et al.; Free Radic. Biol. Med. 86, 308 (2015), Abstract
- Therapeutic targeting of mitochondrial superoxide in hypertension: A.E. Dikalova, et al.; Circ. Res. 107, 106 (2010), Abstract
- Mitochondrial oxidative stress and dysfunction in myocardial remodelling: H. Tsutsui, et al.; Cardiovasc. Res. 81, 449 (2009), Abstract — Full Text
- A mitochondria-targeted nitroxide is reduced to its hydroxylamine by ubiquinol in mitochondria: J. Trnka, et al.; Free Radic. Biol. Med. 44, 1406 (2008), Abstract
- TNF-alpha-induced mitochondrial oxidative stress and cardiac dysfunction: restoration by superoxide dismutase mimetic Tempol: N. Mariappan, et al.; Am. J. Physiol. Heart Circ. Physiol. 293, H2726 (2007), Abstract
- The role of oxidant stress in angiotensin II-mediated contraction of human resistance arteries in the state of health and the presence of cardiovascular disease: M.B. Hussain, et al.; Vascul. Pharmacol. 45, 395 (2006), Abstract
- TEMPOL, a membrane-permeable radical scavenger, attenuates peroxynitrite- and superoxide anion-enhanced carrageenan-induced paw edema and hyperalgesia: a key role for superoxide anion: M.M. Khattab; Eur. J. Pharmacol. 548, 167 (2006), Abstract
- Neuroprotective effects of the stable nitroxide compound Tempol on 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in the Nerve Growth Factor-differentiated model of pheochromocytoma PC12 cells: T. Lipman, et al.; Eur. J. Pharmacol. 549, 50 (2006), Abstract
- The nitroxide Tempol modulates anthracycline resistance in breast cancer cells: M.B. Gariboldi, et al.; Free Radic. Biol. Med. 40, 1409 (2006), Abstract
- Probing the intracellular redox status of tumors with magnetic resonance imaging and redox-sensitive contrast agents: F. Hyodo, et al.; Cancer Res. 66, 9921 (2006), Abstract
- The effects of tempol, 3-aminobenzamide and nitric oxide synthase inhibitors on acoustic injury of the mouse cochlea: H. Murashita, et al.; Hear. Res. 214, 1 (2006), Abstract
- Acute effects of the superoxide dismutase mimetic tempol on split kidney function in two-kidney one-clip hypertensive rats: G.S. Guron, et al.; J. Hypertens. 24, 387 (2006), Abstract
- Systemic arterial pressure response to two weeks of Tempol therapy in SHR: involvement of NO, the RAS, and oxidative stress: L. Yanes, et al.; Am. J. Physiol. Regul. Integr. Comp. Physiol. 288, R903 (2005), Abstract
- Cancer chemoprevention by the antioxidant tempol acts partially via the p53 tumor suppressor: L. Erker, et al.; Hum. Mol. Genet. 14, 1699 (2005), Abstract
- Tempol, one of nitroxides, is a novel ultraviolet-A1 radiation protector for human dermal fibroblasts: S.X. Yan, et al.; J. Dermatol. Sci. 37, 137 (2005), Abstract
- Neuroprotective effects of TEMPOL in central and peripheral nervous system models of Parkinson’s disease: Q. Liang, et al.; Biochem. Pharmacol. 70, 1371 (2005), Abstract
- Antioxidant enzymes and effects of tempol on the development of hypertension induced by nitric oxide inhibition: J. Sainz, et al.; Am. J. Hypertens. 18, 871 (2005), Abstract
- Tempol lowers blood pressure and sympathetic nerve activity but not vascular O2- in DOCA-salt rats: H. Xu et al.; Hypertension 43, 329 (2004), Abstract
- The superoxide dismutase mimetic, tempol, blunts right ventricular hypertrophy in chronic hypoxic rats: B. Elmedal et al.; Br. J. Pharmacol. 141, 105 (2004), Abstract
- Nitroxide TEMPOL impairs mitochondrial function and induces apoptosis in HL60 cells: E. Monti, et al.; J. Cell. Biochem. 82, 271 (2001), Abstract
- Spin trapping agents (Tempol and POBN) protect HepG2 cells overexpressing CYP2E1 against arachidonic acid toxicity: M.J. Perez & A.I. Cederbaum; Free Radic. Biol. Med. 30, 734 (2001), Abstract
- The nitroxide tempol induces oxidative stress, p21(WAF1/CIP1), and cell death in HL60 cells: M.B. Gariboldi, et al.; Free Radic. Biol. Med. 29, 633 (2000), Abstract
- Effects of the superoxide dismutase-mimic compound TEMPOL on oxidant stress-mediated endothelial dysfunction: A.I. Haj-Yehia, et al.; Antioxid. Redox Signal. 1, 221 (1999), Abstract
- Tempol inhibits neutrophil and hydrogen peroxide-mediated DNA damage: S.M. Hahn, et al.; Free Radic. Biol. Med. 23, 879 (1997), Abstract
- Stable nitroxide radicals protect lipid acyl chains from radiation damage: A.M. Samuni & Y. Barenholz; Free Radic. Biol. Med. 22, 1165 (1997), Abstract
- A novel antioxidant alleviates heat hyperalgesia in rats with an experimental painful peripheral neuropathy: M. Tal; Neuroreport 7, 1382 (1996), Abstract
- Protective effect of 4-hydroxy-TEMPO, a low molecular weight superoxide dismutase mimic, on free radical toxicity in experimental pancreatitis: Z. Sledzinski, et al.; Int. J. Pancreatol. 18, 153 (1995), Abstract
- Tempol, a stable free radical, is a novel murine radiation protector: S.M. Hahn, et al.; Cancer Res. 52, 1750 (1992), Abstract
- Inhibition of oxygen-dependent radiation-induced damage by the nitroxide superoxide dismutase mimic, tempol: J.B. Mitchell, et al.; Arch. Biochem. Biophys. 289, 62 (1991), Abstract
- Measurement of intracellular oxygen concentration using the spin label TEMPOL: P.D. Morse, 2nd & H.M. Swartz; Magn. Reson. Med. 2, 114 (1985), Abstract
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