Home Shop Temozolomide

Temozolomide

ALX-420-044

Datasheet
Manual
SDS
CofA

Already have an account?

ALX-420-044-M025 — 25 mg

$117.00

Temozolomide quantity
ALX-420-044-M100 — 100 mg

$403.00

Temozolomide quantity
ALX-420-044-M500 — 500 mg

$1,334.00

Temozolomide quantity

AGT inhibitor

Antitumor and antiangiogenic compound. DNA alkylating agent. Induces G2/M arrest and apoptosis through adduction of a methyl group to O6 position of guanine in genomic DNA. Inactivates DNA repair protein O(6)-alkylguanine DNA alkyltransferase (AGT) in base excision repair (BER) pathway. Chemotherapeutic agent. Modifies drug resistance.

Shipping: Available products typically ship within 24/48h, via priority shipping.

Do you need support? Contact Customer Service or Technical Support.

Online Account
Access or Create Your Account

Product Details

Alternative Name	8-Carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one
Appearance	White to off-white crystalline powder.
CAS	85622-93-1
Couple Target	DNA alkyltransferase
Couple Type	Inhibitor
Formula	C₆H₆N₆O₂
MI	14: 9139
MW	194.2
Purity	≥98% (HPLC)
RTECS	NJ5927050
Solubility	Soluble in DMSO; slightly soluble in water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Targeting Hyaluronan Interactions for Glioblastoma Stem Cell Therapy: Hartheimer, J. S., Park, S., et al.; Cancer Microenviron. 12, 47 (2019), Abstract
Improved effects of honokiol on temozolomide-induced autophagy and apoptosis of drug-sensitive and -tolerant glioma cells: C.C. Chio, et al.; BMC Cancer 18, 379 (2018), Abstract — Full Text
Hedgehog/Gli1 signaling pathway regulates MGMT expression and chemoresistance to temozolomide in human glioblastoma: K. Wang, et al.; Cancer Cell Int. 17, 117 (2017), Abstract — Full Text
Underexpression of HOXA11 Is Associated with Treatment Resistance and Poor Prognosis in Glioblastoma: Y.B. Se, et al.; Cancer Res. Treat. 49, 387 (2017), Abstract — Full Text
Direct modification of the 5-HT3 receptor current by some anticancer drugs: Y. Nakamura, et al.; Eur. J. Pharmacol. 821, 21 (2017), Abstract
Temozolomide for the treatment of metastatic melanoma: a systematic review: I. Quirt, et al.; Oncologist 12, 1114 (2007), (Review), Abstract — Full Text
Concomitant treatment of brain metastasis with whole brain radiotherapy [WBRT] and temozolomide [TMZ] is active and improves quality of life: R. Addeo, et al.; BMC Cancer 7, 18 (2007), Abstract — Full Text
Mutagenic potential of temozolomide in bone marrow cells in vivo: H. Geiger, et al.; Blood 107, 3010 (2006), Abstract — Full Text
Inhibition of angiogenesis by non-toxic doses of temozolomide: H. Kurzen, et al.; Anticancer Drugs 14, 515 (2003), Abstract
Temozolomide induces apoptosis and senescence in glioma cells cultured as multicellular spheroids: W. Gunther, et al.; Br. J. Cancer 88, 463 (2003), Abstract

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Datasheet

Certificate of Analysis

Please enter the lot number as featured on the product label

Lot No. :

SDS

Enzo Life Science provides GHS Compliant SDS

If your language is not available please fill out the SDS request form

Your Cart

Your Cart

Temozolomide

ALX-420-044

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

Change Country

Tell us about You

Tell us about your paper

Tell us about You

Tell us about your project