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UCH-L3 inhibitor

Novel inhibitor of ubiquitin C-terminal hydrolase L3 (IC₅₀ = 0.6µM). Displays 125-fold greater selectivity over UCH-L1 (IC₅₀ = 75µM).

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Alternative Name	4,5,6,7-Tetrachloroindan-1,3-dione
Appearance	Orange solid.
CAS	30675-13-9
Couple Target	Deconjugating enzyme [DCE], UCH
Couple Type	Inhibitor
Formula	C₉H₂Cl₄O₂
MW	283.9
Purity	≥95% (TLC)
Solubility	Soluble in DMSO (25mg/ml).

Use/Stability	As indicated on product label or CoA when stored as recommended. Store solutions at -20°C for up to 3 months.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Mechanisms, biology and inhibitors of deubiquitinating enzymes: K.R. Love, et al.; Nat. Chem. Biol. 3, 697 (2007), Abstract

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