Tau-383 (0N4R variant) (human), (recombinant)

The tau proteins are major neuronal microtubule-associated proteins that function in the stabilization of microtubules and accumulate in various abnormal filaments including neurofibrillary tangles, neuropil threads and amyloid plaques in the pathology of Alzheimer’s disease. Six tau isoforms are derived from alternative mRNA splice variants that originate from a single gene and result in mature proteins that vary in size from 352 to 441 amino acids (36.8 to 45.9 kDa). The six isoforms differ from one another in having three or four microtubule binding repeats (R) and two, one or zero amino terminal inserts (N). While the fetal brain contains a single isoform of tau (Tau-352), the adult brain has several isoforms.