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BML-PI133

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Inhibitor of TNF-α processing

Inhibitor of TNF-α processing. Inhibits TACE and MMPs in vitro.

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Product Details

Alternative Name	IC1, N-[2-[2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-L-alaninamide
Appearance	White powder.
CAS	143457-40-3
Formula	C₂₄H₃₂N₄O₅
MW	456.5
Purity	≥96% (HPLC)
Sequence	N-(R)-(2-(Hydroxyaminocarbonyl)methyl)-4-methylpentanoyl-L-naphthylalanyl-L-alanine amide

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Shed CNTNAP2 ectodomain is detectable in CSF and regulates Ca2+ homeostasis and network synchrony via PMCA2/ATP2B2: Martín-de-Saavedra, M. D., Dos Santos, M., et al.; Neuron 110, 627 (2022), Abstract
Vaccine-induced ICOS+CD38+ circulating Tfh are sensitive biosensors of age-related changes in inflammatory pathways: Herati, R. S., Silva, L. V., et al.; Cell Rep. Med. 2, 100262 (2021), Abstract
Astragaloside III activates TACE/ADAM17-dependent anti-inflammatory and growth factor signaling in endothelial cells in a p38-dependent fashion: Wang, H., Yuan, R., et al.; Phytother. Res. 34, 1096 (2020), Abstract
MMP14 empowers tumor-initiating breast cancer cells under hypoxic nutrient-depleted conditions: L.E. Hillebrand, et al.; FASEB J. 33, 4124 (2019), Abstract
Hydroxy‐Safflower Yellow A inhibits the TNFR1‐Mediated Classical NF‐κB Pathway by Inducing Shedding of TNFR1: H. Wang, et al.; Phytother. Res. 30, 790 (2016), Abstract
A comparative study on inhibition of total astragalus saponins and astragaloside IV on TNFR1-mediated signaling pathways in arterial endothelial cells: S.Q. Liu, et al.; PLoS One. 9, e101504 (2014), Abstract — Full Text
Matrix metalloproteinase-8 plays a pivotal role in neuroinflammation by modulating TNF-α activation: E.J. Lee, et al.; J. Immunol. 193, 2384 (2014), Abstract
Accelerated receptor shedding inhibits kidney injury molecule-1 (KIM-1)-mediated efferocytosis: R. Gandhi, et al.; Am. J. Physiol. Renal. Physiol. 307, F205 (2014), Abstract
Overexpression of TNF-α-converting enzyme in fibroblasts augments dermal fibrosis after inflammation: S. Fukaya, et al.; Lab. Invest. 93, 72 (2013), Abstract