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Tamoxifen . citrate

ALX-550-095

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PKC inhibitor

Antiestrogen with anti-cancer activity. Selective protein kinase C (PKC) inhibitor and induces PKC epsilon translocation. Induces apoptosis in estrogen receptor-negative human cancer cell lines.

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Product Details

Alternative Name	(Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethyl-ethanamine . citrate
Appearance	White to off-white powder.
CAS	54965-24-1
Couple Target	PKC
Couple Type	Inhibitor
Formula	C₂₆H₂₉NO . C₆H₈O₇
Identity	Determined by IR.
MI	14: 9048
MW	371.5 . 192.1
Purity	≥99% (Assay)
RTECS	KH2387000
Solubility	Soluble in methanol or ethanol; very slightly soluble in water or acetone.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

RORgt+ c-Maf+ Vg4+ gd T cells are generated in the adult thymus but do not reach the periphery: T. Yang, et al.; Cell Rep. 42, 113230 (2023), Abstract
Progesterone limits the tumor-promoting effects of the beta-subunit of human chorionic gonadotropin via non-nuclear receptors: Sarkar, M., Sharma, H., et al.; iScience 25, 104527 (2022), Abstract
Niche-mediated repair of airways is directed in an occupant-dependent manner: H. Lyu, et al.; Cell Rep. 41, 111863 (2022), Abstract
Mitochondrial Dysfunction Leads to Cortical Under-Connectivity and Cognitive Impairment: Fernandez, A., Meechan, D. W., et al.; Neuron 102, 1127 (2019), Abstract
Loss of the N-terminal methyltransferase NRMT1 increases sensitivity to DNA damage and promotes mammary oncogenesis: Bonsignore, L. A., Butler, J. S., et al.; Oncotarget 6, 12248 (2015), Abstract
Is tamoxifen the Rosetta stone for breast cancer?: V.C. Jordan; J. Natl. Cancer Inst. 95, 338 (2003), Abstract
Tamoxifen: a most unlikely pioneering medicine: V.C. Jordan; Nat. Rev. Drug Discov. 2, 205 (2003), Abstract
Tamoxifen for prevention of breast cancer: R.J. Cersosimo; Ann. Pharmacother. 37, 268 (2003), Abstract
Update on clinical role of tamoxifen: J.R. Benson and V. Pitsinis; Curr. Opin. Obstet. Gynecol. 15, 13 (2003), Abstract
Pharmacodynamics of tamoxifen and its 4-hydroxy and N-desmethyl metabolites: activation of caspases and induction of apoptosis in rat mammary tumors and in human breast cancer cell lines: S. Mandlekar, et al.; Cancer Res. 60, 6601 (2000), Abstract — Full Text

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Last modified: May 29, 2024

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Tamoxifen . citrate

ALX-550-095

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