T0901317

ALX-270-309

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LXR activator

Potent agonist (EC₅₀=50nM) of the orphan nuclear hormone receptor (liver X receptor; LXR). Inhibitor of human sex hormone-dependent cancer cell lines.

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Product Details

Alternative Name	N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide
Appearance	White to off-white crystalline solid.
CAS	293754-55-9
Couple Target	LXR
Couple Type	Activator, Ligand
Formula	C₁₇H₁₂NF₉O₃S
Identity	Determined by MS.
MW	481.3
Purity	≥98% (HPLC)
Solubility	50mg/ml soluble in 100% ethanol, DMSO, dimethyl formamide or any organic solvent; also soluble in a 1:1 solution of DMSO:PBS, pH 7.2 (500µg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. We do not recommend storing the aqueous solutions for more than one day.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Validation and application of a novel cholesterol efflux assay using immobilized liposomes as a substitute for cultured cells: Y. Horiuchi, et al.; Biosci. Rep. 38, BSR20180144 (2018), Abstract — Full Text
AMPK activates LXRα and ABCA1 expression in human macrophages: M. Kemmerer, et al.; Int. J. Biochem. Cell Biol. 16, 30154 (2016), Application(s): Cell culture using human monocytic cells, Abstract
Liver X receptor reduces proliferation of human oral cancer cells by promoting cholesterol efflux via up-regulation of ABCA1 expression: Kaneko, T., Kanno, C., et al.; Oncotarget 6, 33345 (2015), Abstract
The liver X receptor agonist T0901317 acts as androgen receptor antagonist in human prostate cancer cells: C.P. Chuu et al.; Biochem. Biophys. Res. Commun. 357, 341 (2007), Abstract
Antiproliferative effect of liver X receptor agonists on LNCaP human prostate cancer cells: J. Fukuchi, et al.; Cancer Res. 64, 7686 (2004), Abstract
LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes: B.A. Laffitte, et al.; PNAS 98, 507 (2001), Abstract — Full Text
Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands: R.A. DeBose-Boyd, et al.; PNAS 98, 1477 (2001), Abstract — Full Text
Role of LXRs in control of lipogenesis: J.R. Schultz, et al.; Genes Dev. 14, 2831 (2000), Abstract — Full Text
Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers: J.J. Repa, et al.; Science 289, 1524 (2000), Abstract

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T0901317

ALX-270-309

Product Details

Handling & Storage

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