T0070907

BML-GR212

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PPAR ligand

Potent and selective PPARγ antagonist. T0070907 blocks PPARγ function in both cell-based reporter gene and adipocyte differentiation assays. It inhibits growth and survival of hepatocellular carcinoma cells and squamous cell carcinoma cell lines by interfering with cell adhesion “anoikis”.

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Product Details

Alternative Name	2-Chloro-5-nitro-N-4-pyridinylbenzamide
Appearance	Off-white solid.
CAS	313516-66-4
Couple Target	PPAR
Couple Type	Ligand
Formula	C₁₂H₈ClN₃O₃
MW	277.7
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (>25 mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at room temperature for up to 1 year. Store solutions at-20°C for up to 3 months.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

miR-223 Plays a Key Role in Obesogen-Enhanced Adipogenesis in Mesenchymal Stem Cells and in Transgenerational Obesity: R.C. Chang, et al.; Endocrinology 164, bqad027 (2023), Abstract
Cannabidiol promotes adipogenesis of human and mouse mesenchymal stem cells via PPARγ by inducing lipogenesis but not lipolysis: R.C. Chang, et al.; Biochem. Pharmacol. 197, 114910 (2022), Abstract
Effects of Perinatal Exposure to Dibutyltin Chloride on Fat and Glucose Metabolism in Mice, and Molecular Mechanisms, in Vitro: R. Chamorro-Garcia, et al.; Environ. Health Perspect. 126, 57006 (2018), Abstract — Full Text
Peroxisome proliferator-activated receptor gamma inhibition prevents adhesion to the extracellular matrix and induces anoikis in hepatocellular carcinoma cells: K. L. Schaefer, et al.; Cancer Res. 65, 2251 (2005), Abstract — Full Text
Critical role of peroxisome proliferator-activated receptor gamma on anoikis and invasion of squamous cell carcinoma: T. Masuda, et al.; Clin. Cancer Res. 11, 4012 (2005), Abstract — Full Text
PPARgamma antagonists exacerbate neural antigen-specific Th1 response and experimental allergic encephalomyelitis: H. P. Raikwar, et al.; J. Neuroimmunol. 167, 99 (2005), Abstract
T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities: G. Lee, et al.; J. Biol. Chem. 277, 19649 (2002), Abstract — Full Text

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T0070907

BML-GR212

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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