T-2 Toxin

ALX-630-101

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Monoamine oxidase inhibitor

Mycotoxin. Induces DNA damage and apoptosis. Increases blood-brain barrier permeability and inhibits monoamine oxidase activity in the brain.

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Product Details

Alternative Name	4β,15-Diacetoxy-3α-hydroxy-8α-(3-methylbutyryloxy)-12,13-epoxytrichothec-9-ene
Appearance	White to off-white crystalline solid.
CAS	21259-20-1
Couple Target	Monoamine oxidase
Couple Type	Inhibitor
Formula	C₂₄H₃₄O₉
MW	466.5
Purity	≥98% (TLC)
RTECS	YD0100000
Solubility	Soluble in methylene chloride (5mg/ml) or chloroform.
Source	Isolated from Fusarium Sporotrichoides.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Iturin A Strongly Inhibits the Growth and T-2 Toxin Synthesis of Fusarium oxysporum: A Morphological, Cellular, and Transcriptomics Study: M. Hua, et al.; Foods 12, 1278 (2023), Abstract
Mycotoxin occurrence on baled and pit silages collected in Co. Meath: C. McElinney, et al.; Irish J. Agr. Food. Res. 54, 87 (2015), Application(s): Liquid chromatography tandem mass spectrometry for Mycotoxin analysis, Full Text
Cytotoxicity and related effects of T-2 toxin on cultured Vero cells: C. Bouaziz, et al.; Toxicon 48, 343 (2006), Abstract
Development of apoptosis and changes in lymphocyte subsets in thymus, mesenteric lymph nodes and Peyer’s patches of mice orally inoculated with T-2 toxin: T. Nagata, et al.; Exp. Toxicol. Pathol. 53, 309 (2001), Abstract
Kinetics of apoptosis-related genes mRNA expression in the dorsal skin of hypotrichotic WBN/ILA-ht rats after topical application of T-2 toxin: S.M. Albarenque, et al.; Exp. Toxicol. Pathol. 52, 553 (2001), Abstract
Kinetics and distribution of transforming growth factor (TGF)-beta 1 mRNA in the dorsal skin of hypotrichotic WBN/ILA-Ht rats following topical application of T-2 toxin: S.M. Albarenque, et al.; Exp. Toxicol. Pathol. 52, 297 (2000), Abstract
Thymocyte apoptosis by T-2 toxin in vivo in mice is independent of Fas/Fas ligand system: A.M. Murshedul, et al.; Biosci. Biotechnol. Biochem. 64, 210 (2000), Abstract
T-2 toxin-induced apoptosis in hematopoietic tissues of mice: J. Shinozuka, et al.; Toxicol. Pathol. 26, 674 (1998), Abstract
T-2 toxin induces thymic apoptosis in vivo in mice: Z. Islam, et al.; Toxicol. Appl. Pharmacol. 148, 205 (1998), Abstract
Apoptotic cellular damage in mice after T-2 toxin-induced acute toxicosis: T. Ihara, et al.; Nat. Toxins 5, 141 (1997), Abstract

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Alternative Name	15-Acetoxy-3α,4β-dihydroxy-8α-(3-methylbutyryloxy)-12,13-epoxytrichothec-9-ene
CAS	26934-87-2
Purity	≥98% (TLC)

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T-2 Toxin

ALX-630-101

Product Details

Handling & Storage

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