Home Shop Syk monoclonal antibody (SYK-01)

Syk monoclonal antibody (SYK-01)

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Application	ICC, IHC (PS), IP, WB
Clone	SYK-01
Formulation	Liquid. In PBS, pH 7.4, containing 15mM sodium azide.
Host	Mouse
Immunogen	Recombinant fragment (aa 5-360) of human Syk.
Isotype	IgG1
Purity Detail	Protein A-affinity purified.
Recommendation Dilutions/Conditions	Immunohistochemistry (paraffin sections, 5µg/ml)Western Blot (1-2µg/ml, 60min.)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application.
Species Reactivity	Human, Mouse, Rat
UniProt ID	P43405
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling	Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Long Term Storage	+4°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

A novel lipid raft-associated glycoprotein, TEC-21, activates rat basophilic leukemia cells independently of the type 1 Fc epsilon receptor: I. Halova, et al.; Int. Immunol. 14, 213 (2002), Abstract
Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation: V. Parravicini, et al.; Nat. Immunol. 3, 741 (2002), Abstract
Vav1 regulates phospholipase cgamma activation and calcium responses in mast cells: T.S. Manetz, et al.; Mol. Cell. Biol. 21, 3763 (2001), Abstract — Full Text
Structure-function analysis of Lyn kinase association with lipid rafts and initiation of early signaling events after Fcepsilon receptor I aggregation: M. Kovarova, et al.; Mol. Cell. Biol. 21, 8318 (2001), Abstract — Full Text
The Src homology 2 domain of Vav is required for its compartmentation to the plasma membrane and activation of c-Jun NH(2)-terminal kinase 1: R. Arudchandran, et al.; J. Exp. Med. 191, 47 (2000), Abstract — Full Text
Requirement for a negative charge at threonine 60 of the FcRgamma for complete activation of Syk: P.G. Swann, et al.; J. Biol. Chem. 274, 23068 (1999), Abstract — Full Text
Direct interaction of Syk and Lyn protein tyrosine kinases in rat basophilic leukemia cells activated via type I Fc epsilon receptors: M. Amoui, et al.; Eur. J. Immunol. 27, 321 (1997), Abstract
Protein tyrosine kinase Syk is involved in Thy-1 signaling in rat basophilic leukemia cells: P. Tolar, et al.; Eur. J. Immunol. 27, 3389 (1997), Abstract

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