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Swainsonine

BML-S112

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Lysosomal alpha-mannosidase inhibitor

Reversibly inhibits the active site of lysosomal α-mannosidase. Also inhibits the growth of tumors and prevents metastasis in murine models. Could inhibit cell proliferation in vitro and the growth of human gastric carcinoma in vivo. Blocks the processing of high mannose oligosaccharides to form complex type oligosaccharides.^Immunomodulator.

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Product Details

Alternative Name	8α,β-Octahydroindolizidine-1α,2α,8β-triol
Appearance	White to off-white solid.
CAS	72741-87-8
Couple Target	Lysosomal alpha-mannosidase, Mannosidase
Couple Type	Inhibitor
Formula	C₈H₁₅NO₃
MW	173.2
Purity	≥98% (TLC)
Solubility	Soluble in 100% ethanol, DMSO, methanol or water (10mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored at +4°C. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Inhibition of the growth of human gastric carcinoma in vivo and in vitro by swainsonine: J.Y. Sun, et al.; Phytomedicine 14, 353 (2007), Abstract
Swainsonine stimulates bone marrow cell proliferation and differentiation in different strains of inbred mice: O.A. Oredipe, et al.; Pharmacol. Res. 47, 69 (2003), Abstract
Swainsonine protects both murine and human haematopoietic systems from chemotherapeutic toxicity: J.L. Klein, et al.; Br. J. Cancer 80, 87 (1999), Abstract
Purification and characterization of Ca2+/calmodulin-dependent protein kinase V from rat cerebrum: H. Mochizuki, et al.; J. Biol. Chem. 268, 9143 (1993), Abstract — Full Text
Stimulation of DNA synthesis in murine lymphocytes by the drug swainsonine: immunomodulatory properties: S.L. White, et al.; BBRC 150, 615 (1988), Abstract
Effect of swainsonine on the processing and turnover of lysosomal beta-galactosidase and beta-glucuronidase from mouse peritoneal macrophages: J.E. Tropea, et al.; J. Biol. Chem. 263, 4309 (1988), Abstract
Augmentation of murine natural killer cell activity by swainsonine, a new antimetastatic immunomodulator: M.J. Humphries, et al.; Cancer Res. 48, 1410 (1988), Abstract
Effect of trimming inhibitors on the secretion and biological activity of a murine IgE monoclonal antibody: D.A. Granato & J.R. Neeser; Mol. Immunol. 24, 849 (1987), Abstract
Swainsonine inhibits glycoprotein degradation by isolated rat liver lysosomes: J.R. Winkler & H.L. Segal; J. Biol. Chem. 259, 15369 (1984), Abstract
Inhibitors of glycoprotein synthesis: A.D. Elbein; Meth. Enzymol. 98, 135 (1983), Abstract

Last modified: May 29, 2024

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Swainsonine

BML-S112

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