SUMO-4 (human), (recombinant) (His-tag)

SUMO-4 is a member of the SUMO (small ubiquitin-related modifier) family of ubiquitin-like proteins involved in the regulation of the cellular functions of a wide variety of proteins, although there remains considerable debate as to whether this is a real and expressed gene product.

It has been reported that upon oxidative stress, SUMO-4 conjugates to various anti-oxidant enzymes, chaperones, and stress defence proteins, whereas under standard physiological conditions it is rapidly degraded. Subsequent proteomic analysis of SUMO-4 conjugates identified substrates implicated in the regulation of DNA repair and synthesis, RNA processing, protein degradation and glucose metabolism, suggesting a role for SUMO-4 in the regulation of intracellular stress.

The M55V substitution in SUMO-4 has been associated with type I diabetes.