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Sulindac sulfone

BML-AP201

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Sulindac metabolite

Induces apoptosis but does not inhibit cyclooxygenase. Inhibits growth and induces apoptosis in human cancer cell lines. Metabolite of Sulindac (Prod. No. ALX-430-105).

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Product Details

Alternative Name	Z-5-Fluoro-2-methyl-1-[p-(methyl-sulfonyl)benzylidene]indene-3-acetic acid
Appearance	Yellow solid.
CAS	59864-04-9
Formula	C₂₀H₁₇FO₄S
MW	372.4
Purity	≥94% (HPLC)
Solubility	Soluble in DMSO (>25mg/ml) or 100% ethanol (3mg/ml, warm).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Sulindac inhibits activation of the NF-kappaB pathway: Y. Yamamoto, et al.; J. Biol. Chem. 274, 27307 (1999), Abstract
Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis: G.A. Piazza, et al.; Cancer Res. 55, 3110 (1995), Abstract

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Sulindac sulfone

BML-AP201

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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