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Sulindac sulfide

BML-AP200

6 citations

  • BML-AP200-0005   —   5 mg
    $88.00
  • BML-AP200-0025   —   25 mg
    $277.00

Active metabolite of sulindac (Prod. No. ALX-430-105). Inhibits cyclooxygenase. More selective for PGHS-1 (ID50=0.5 µM) over PGHS-2 (ID50=14 µM). Induces apoptosis by a cyclooxygenase-independent mechanism. Inhibits colorectal cancer growth and γ-secretase. NF-κB inhibitor. Inhibits Ras signaling.

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Regulatory Status

RUO – Research Use Only