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Potent, ATP-competitive and cell permeable inhibitor of tyrosine kinases (VEGF-R2 IC50=27nM, PDGF-Rβ IC50=3nM). Also inhibits wild-type and all mutant forms of Kit in mast cells (IC50‘s=10 to 100nM) resulting in cell cycle arrest and apoptosis. Su11652 was also shown to induce autophagy in MCF-7 cells.
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