SU-5402

• GMP format available

SU-5402 is a potent and selective inhibitor of multiple receptor tyrosine kinases, including vascular endothelial growth factor receptor 2 (VEGFR2), fibroblast growth factor receptor 1 (FGFR1), and platelet-derived growth factor receptor beta (PDGFRB). It has IC50 values of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGFRB, respectively.

Key features and applications include:

• Cancer Research: SU-5402 is used to study the inhibition of angiogenesis and tumor growth by targeting VEGFR2, FGFR1, and PDGFRB pathways.
• Stem Cell Research: It is employed to maintain the pluripotency of embryonic stem cells and to study the differentiation processes.
• Developmental Biology: SU-5402 is utilized to investigate the roles of FGFR and VEGFR in embryonic development and tissue repair.

Relevant disease states include:

• Cancer: SU-5402 has shown antitumor properties and is studied for its potential to inhibit tumor growth in various cancers.
• Neurodegenerative Diseases: It is used in research to study its effects on neural stem cell differentiation, which can be relevant for conditions like Alzheimer’s and Parkinson’s diseases.
• Developmental Disorders: SU-5402 is studied for its role in inhibiting embryonic left-right determination, which can be relevant in understanding certain developmental disorders.