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Streptozotocin

ALX-380-010

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O-GlcNAcase inhibitor

Highly pure O-GlcNAcase inhibitor
Compound commonly used to induce diabetes in vivo
Highly cited

Streptozotocin (STZ) is a glucosamine-nitrosourea widely used as an inhibitor of O-GlcNAcase in b-cells to induce diabetes in rodents. Once entered inside b-cells via the glucose transporter GLUT2, STZ causes alkylation of DNA, activation of poly ADP-ribosylation, depletion of cellular ATP and NAD⁺, generation of superoxide radicals, and ultimately elimination of b-cells. STZ acts also as a nitric oxide (NO) donor and vasorelaxant capable of relaxing phenylephrine-contracted aortic rings at 10µM. STZ is a potent methylating agent for DNA.

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Product Details

Alternative Name	Streptozocin, 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose, STZ
Appearance	White to pale yellow crystalline solid.
CAS	18883-66-4
Couple Target	O-GlcNAcase
Couple Type	Inhibitor
Formula	C₈H₁₅N₃O₇
MI	14: 8832
MW	265.2
Purity	≥97% (HPLC)
RTECS	LZ5775000
Solubility	Soluble in 100% ethanol (200 proof at 0.92mg/ml) or water (nH2O at 102.8mg/ml).
Source	Isolated from Streptomyces achromogenes.
Technical Info / Product Notes	Solutions of Streptozotocin will spontaneously give off NO gas at room temperature. This NO release is slowed, but not completely stopped at -80°C, and the rate of NO release is also impacted by the solvent used (for example, dissolving Streptozotocin in buffers that contain sodium speeds up NO release). Since it does not seem to be possible to completely stop the NO release when streptozotocin is in solution, and the NO donor function is critical to the majority of experimental applications, we recommend that customers make solutions only immediately before use. Note: since streptozotocin is often used to treat animals, the requirement that solutions be made immediately before use can be overwhelming for some users. Therefore, we generally suggest that the material be initially dissolved in ethanol, aliquoted into single use amounts, and then the alcohol evaporated off to produce dry aliquots. NO loss is minimized by doing this procedure with the material on ice, and carrying it out as quickly as possible. The individual dry aliquots can then be easily dissolved immediately before use.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Because solutions of the compound spontaneously give off NO gas at room temperature, we recommend that solutions be made immediately before use.
Long Term Storage	-20°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

PET Imaging of Diabetes-Induced Alterations in Metabolism and Immune Activation: Lynch, S. E., Alsheikh, H. M., et al.; Mol. Imaging Biol. , (2025), Abstract
Efficacy of a Novel Pleiotropic MMP-Inhibitor, CMC2.24, in a Long-Term Diabetes Rat Model with Severe Hyperglycemia-Induced Oral Bone Loss: H.D. Bhatt, et al.; J. Inflamm. Res. 16, 779 (2023), Abstract
Pharmacokinetic assessment of cefpodoxime proxetil in diabetic rats: G. Mittal, et al.; J. Diabetes Metab. Disord. 22, 385 (2022), Abstract
Post-stroke administration of L-4F promotes neurovascular and white matter remodeling in type-2 diabetic stroke mice: M. Zhou, et al.; Front. Neurol. 13, 863934 (2022), Abstract — Full Text
Hirudo Lyophilized Powder Ameliorates Renal Injury in Diabetic Rats by Suppressing Oxidative Stress and Inflammation: F. Yang, et al.; Evid. Based Complement. Alternat. Med. 2021, 6657673 (2021), Abstract — Full Text
Normalizing glucose levels reconfigures the mammary tumor immune and metabolic microenvironment and decreases metastatic seeding: H.A.M. Alsheikh, et al.; Cancer Lett. 517, 24 (2021), Abstract
Novologue Therapy Requires Heat Shock Protein 70 and Thioredoxin-Interacting Protein to Improve Mitochondrial Bioenergetics and Decrease Mitophagy in Diabetic Sensory Neurons: Y.A. Rodriguez, et al.; ACS Chem. Neurosci. 12, 3049 (2021), Abstract
A Novel Modified-Curcumin Promotes Resolvin-Like Activity and Reduces Bone Loss in Diabetes-Induced Experimental Periodontitis: J. Deng, et al.; J. Inflamm. Res. 14, 5335 (2021), Abstract
Carbohydrate response element‐binding protein regulates lipid metabolism via mTOR complex1 in diabetic nephropathy: N. Chen, et al.; J. Cell. Pysiol. 236, 625 (2021), Abstract
C-myc upregulated by high glucose inhibits hacat differentiation by s100a6 transcriptional activation: J. Zhang, et al.; Front. Endocrinol. 12, 676403 (2021), Abstract — Full Text

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Last modified: May 29, 2024

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Streptozotocin

ALX-380-010

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Handling & Storage

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