STO-609

BML-EI389

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CaM kinase kinase inhibitor

STO-609 is a specific CaM kinase kinase (CaM-KK) inhibitor. Ki=0.2μM and 0.04μM for α and β isotypes respectively. Demonstrates >80-fold selectivity for CAM-KK over CaMK1, CaMK2, CaMK4, MLCK, PKA, PKC, and p42 MAPK. Concentrations up to 10μg/ml do not affect cellular viability. It is a tool for exploring the role of the CaM-KK pathway in various physiological processes.

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Product Details

Alternative Name	7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid, acetate salt
Appearance	Yellow solid.
CAS	1173022-21-3
Couple Target	CaM-KK
Couple Type	Inhibitor
Formula	C₁₉H₁₀N₂O₃·C₂H₄O₂
MW	374.3
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (10mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

A temporal Ca 2+-desensitization of myosin light chain kinase in phasic smooth muscles induced by CaMKKß/PP2A pathways: T. Kitazawa, et al.; Am. J. Physiol. Cell Physiol. 321, C549 (2021), Abstract
Antillatoxin, a novel lipopeptide, enhances neurite outgrowth in immature cerebrocortical neurons through activation of voltage-gated sodium channels: S.V. Jabba, et al.; J. Pharmacol. Exp. Ther. 332, 698 (2010), Abstract
Leucine modulates contraction- and insulin-stimulated glucose transport and upstream signaling events in rat skeletal muscle: N. Iwanaka, et al.; J. Appl. Physiol. 108, 274 (2010), Abstract
STO-609, a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase: H. Tokumitsu, et al.; J. Biol. Chem. 277, 15813 (2002), Abstract

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STO-609

BML-EI389

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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