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Apoptosis inducer. Protein kinase inhibitor.
- Model apoptosis inducer
- Potent cell-permeable inhibitor of protein kinases
- Highly cited
Staurosporine is the reference agent for apoptosis induction (1µM in CHO cells). Staurosporine binds to the ATP binding site and inhibits a variety of protein kinases including protein kinase C (PKC), CDK1/cyclin B (IC50~5nM), CDK2/cyclin A (IC50=7nM), CDK4/cyclin D (IC50=3-10µM), CDK5/p25 (IC50=4nM), GSK-3β (IC50=15nM), and Pim-1 kinase (IC50=10nM). Staurosporine does not inhibit PKC-ζ. Staurosporine also inhibits topoisomerase II directly by blocking transfer of phosphodiester bonds from DNA to active site tyrosine. Other than apoptosis and cytotoxicity, some of the biological effects of staurosporine include regulation of eNOS gene expression and relaxation of smooth mucles.
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Product Details
| Alternative Name |
Antibiotic AM-2282 |
|---|---|
| Appearance |
Off-white to green powder. |
| CAS |
62996-74-1 |
| Couple Target |
CDK, MLCK, PKC, Topoisomerase |
| Couple Type |
Inhibitor |
| Formula |
C28H26N4O3 |
| MI |
14: 8802 |
| MW |
466.5 |
| Purity |
≥99% (HPLC) |
| RTECS |
KC655000 |
| Solubility |
Soluble in DMF (25mg/ml), DMSO (25mg/ml), or ethyl acetate. Only slightly soluble in chloroform and methanol. Insoluble in water. |
| Source |
Isolated from Streptomyces staurosporeus. |
| Technical Info / Product Notes |
Replacement for ADI-HPK-112 |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. Stable for at least 2 years after receipt when stored +4°C. |
|---|---|
| Handling |
Protect from light and moisture. Store under inert gas. |
| Long Term Storage |
+4°C |
| Shipping |
Ambient Temperature |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Mesenchymal stem cell-derived apoptotic vesicles regulate irritable bowel syndrome in mice via the 5-HT brain-gut axis: Sun, Y., Wu, D., et al.; Stem Cell Res. Ther. 16, 326 (2025), Abstract
- A bacterial genotoxin reveals a p53-proteasome-LC3 regulatory axis that drives the suppression of autophagy in cells experiencing sublethal DNA damage: Lieu, D. J., Crowder, M. K., et al.; iScience 28, 112118 (2025), Abstract
- Antagonistic nanobodies implicate mechanism of GSDMD pore formation and potential therapeutic application: L.D.J. Schiffelers, et al.; Nat. Commun. 15, 8266 (2024), Abstract
- Autophagy suppression in DNA damaged cells occurs through a newly identified p53-proteasome-LC3 axis: Lieu, D. J., Crowder, M. K., et al.; bioRxiv , (2024)
- Mesenchymal stem cell-derived apoptotic vesicles ameliorate impaired ovarian folliculogenesis in polycystic ovary syndrome and ovarian aging by targeting WNT signaling: Fu, Y., Zhang, M., et al.; Theranostics 14, 3385 (2024), Abstract
- Neuronal autosis is Na+/K+-ATPase alpha 3-dependent and involved in hypoxic-ischemic neuronal death: Depierre, P., Ginet, V., et al.; Cell Death Dis. 15, 363 (2024), Abstract
- Resolvin D2 limits atherosclerosis progression via myeloid cell-GPR18: Lipscomb, M., Walis, S., et al.; FASEB J. 38, e23555 (2024), Abstract
- Bim Expression Influences Choroidal Endothelial Cell Characteristics and Their Response to Therapeutic Intervention: Sheibani, N., Song, Y. S., et al.; Int. J. Mol. Sci. 25, 10254 (2024), Abstract
- Acute high-fat diet impairs macrophage supported intestinal damage resolution: A.A. Hill, et al.; JCI Insight 8, e164489 (2023), Abstract
- Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice: E.B. Faber, et al.; J. Med. Chem. 66, 1928 (2023), Abstract
- Platelet-Derived Apoptotic Vesicles Promote Bone Regeneration via Golgi Phosphoprotein 2 (GOLPH2)-AKT Signaling Axis: Y. Jiang, et al.; ACS Nano 17, 25070 (2023), Abstract
- Combining organotypic tissue culture with light‐sheet microscopy (OTCxLSFM) to study glioma invasion: A. Haydo, et al.; EMBO Rep. 24, e56964 (2023), Abstract
- Lyophilized apoptotic vesicle-encapsulated adhesive hydrogel sponge as a rapid hemostat for traumatic hemorrhage in coagulopathy: Y. Jiang, et al.; J. Nanobiotechnology 21, 407 (2023), Abstract
- Activity-dependent tau cleavage by caspase-3 promotes neuronal dysfunction and synaptotoxicity: Opland, C. K., Bryan, M. R., et al.; iScience 26, 106905 (2023), Abstract
- Encapsulation of Nano-Bortezomib in Apoptotic Stem Cell-Derived Vesicles for the Treatment of Multiple Myeloma: Cao, Z., Li, P., et al.; Small 19, e2301748 (2023), Abstract
- Helicobacter pylori-induced reactive oxygen species direct turnover of CSN-associated STAMBPL1 and augment apoptotic cell death: S. Chaithongyot & M. Naumann; Cell. Mol. Life Sci. 79, 86 (2022), Abstract
- Apoptotic extracellular vesicles are metabolized regulators nurturing the skin and hair: L. Ma, et al.; Bioact. Mater. 19, 626 (2022), Abstract — Full Text
- Apoptotic vesicles inherit SOX2 from pluripotent stem cells to accelerate wound healing by energizing mesenchymal stem cells: Y. Qu, et al.; Acta Biomater. 149, 258 (2022), Abstract
- Fluorescence imaging detection of nanodomain redox signaling events at organellar contacts: D.M. Booth, et al.; STAR Protoc. 3, 101119 (2022), Abstract — Full Text
- Oligodendroglia-derived extracellular vesicles activate autophagy via LC3B/BAG3 to protect against oxidative stress with an enhanced effect for HSPB8 enriched vesicles: B. Van den Broek, et al.; Cell. Commun. Signal. 20, 58 (2022), Abstract — Full Text
- Protocol for differential centrifugation-based separation and characterization of apoptotic vesicles derived from human mesenchymal stem cells: D. Chen, et al.; STAR Protoc. 3, 101695 (2022), Abstract — Full Text
- LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nucleus: Z. Wu, et al.; EMBO J. 41, e112006 (2022), Abstract
- Septins promote caspase activity and coordinate mitochondrial apoptosis: Van Ngo, H., Robertin, S., et al.; Cytoskeleton (Hoboken) 80, 254 (2022), Abstract
- Oxidative bursts of single mitochondria mediate retrograde signaling toward the ER: D.M. Booth, et al.; Mol. Cell 81, 3866 (2021), Abstract — Full Text
- Epigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease: J. Hey, et al.; Nat. Commun. 12, 6520 (2021), Abstract
- Apoptotic Extracellular Vesicles Ameliorate Multiple Myeloma by Restoring Fas-Mediated Apoptosis: J. Wang, et al.; ACS Nano 15, 14360 (2021), Abstract
- Autophagy displays divergent roles during intermittent amino acid starvation and toxic stress-induced senescence in cultured skeletal muscle cells: D. Bloemberg & J. Quadilatero; J. Cell. Physiol. 236, 3099 (2021), Application(s): Mouse skeletal myoblasts (C2C12) treatment, Abstract
- Staurosporine-induced cleavage of apoptosis-inducing factor in human fibrosarcoma cells is independent of matrix metalloproteinase-2: W. Bassiouni, et al.; Can. J. Physiol. Pharmacol. , (2021), Abstract
- Chronic irradiation of human cells reduces histone levels and deregulates gene expression: D.J. Lowe, et al.; Sci. Rep. 10, 2200 (2020), Abstract — Full Text
- Docosahexaenoic acid protection against palmitic acid‐induced lipotoxicity in NGF‐differentiated PC12 cells involves enhancement of autophagy and inhibition of apoptosis and necroptosis: M.L. Montero, et al.; J. Neurochem. 155, 559 (2020), Abstract — Full Text
- Gold/alpha-lactalbumin nanoprobes for the imaging and treatment of breast cancer: J. Yang, et al.; Nat. Biomed. Eng. 4, 686 (2020), Abstract — Full Text
- Mithramycin selectively attenuates DNA-damage-induced neuronal cell death: O. Makarevich, et al.; Cell Death Dis. 11, 587 (2020), Abstract — Full Text
- Resolvin D1 promotes the targeting and clearance of necroptotic cells: B.D. Gerlach, et al.; Cell Death Differ. 27, 525 (2020), Abstract — Full Text
- Divergent effects of canonical and non-canonical TGF-β signalling on mixed contractile-synthetic smooth muscle cell phenotype in human Marfan syndrome aortic root aneurysms: A.J. Pedroza, et al.; J. Cell. Mol. Med. 24, 2369 (2020), Abstract — Full Text
- Loss of Peter Pan (PPAN) Affects Mitochondrial Homeostasis and Autophagic Flux: D.P. Dannheisig, et al.; Cells 8, 894 (2019), Abstract — Full Text
- Kinase-Based Screening of Marine Natural Extracts Leads to the Identification of a Cytotoxic High Molecular Weight Metabolite from the Mediterranean Sponge Crambe tailliezi: T.N. Nguyen, et al.; Mar. Drugs 17, 569 (2019), Abstract — Full Text
- Membrane Localization of HspA1A, a Stress Inducible 70-kDa Heat-Shock Protein, Depends on Its Interaction with Intracellular Phosphatidylserine: A.D. Bilog, et al.; Biomolecules 9, 152 (2019), Abstract — Full Text
- Collapse of the Plasmacytoid Dendritic Cell Compartment in Advanced Cutaneous Melanomas by Components of the Tumor Cell Secretome: Vescovi, R., Monti, M., et al.; Cancer Immunol. Res. 7, 12 (2019), Abstract
- Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in STAT2: Duncan, C. J. A., Thompson, B. J., et al.; Sci. Immunol. 4, (2019), Abstract
- Loperamide, pimozide, and STF-62247 trigger autophagy-dependent cell death in glioblastoma cells: S. Zielke, et al.; Cell Death Dis. 9, 994 (2018), Abstract — Full Text
- A Rapid and Precise Mutation-Activated Fluorescence Reporter for Analyzing Acute Mutagenesis Frequency: Birnbaum, M. D., Nemzow, L., et al.; Cell Chem. Biol. 25, 1038 (2018), Abstract
- ATG5 Promotes Death Signaling in Response to the Cyclic Depsipeptides Coibamide A and Apratoxin A: Wan, X., Serrill, J. D., et al.; Mar. Drugs 16, (2018), Abstract
- Cobalamin-Associated Superoxide Scavenging in Neuronal Cells Is a Potential Mechanism for Vitamin B12-Deprivation Optic Neuropathy: W. Chan, et al.; Am. J. Pathol. 188, 160 (2017), Abstract
- Pyroptosis and apoptosis pathways engage in bidirectional crosstalk in monocytes and macrophages: C.Y. Taabazuing, et al.; Cell Chem. Biol. 24, 507 (2017), Abstract — Full Text
- CDK4/6 inhibition triggers anti-tumour immunity: Goel, S., Decristo, M. J., et al.; Nature 548, 471 (2017), Abstract
- Triggering of Suicidal Erythrocyte Death by Bexarotene: A. Al Mamun Bhuyan, et al.; Cell. Physiol. Biochem. 40, 1239 (2016), Abstract
- Artesunate induces ROS-dependent apoptosis via a Bax-mediated intrinsic pathway in Huh-7 and Hep3B cells: Y. Pang, et al.; Exp. Cell Res. 16, 30161 (2016), Application(s): Flow cytometry analysis, Abstract
- Recurrent Loss of NFE2L2 Exon 2 Is a Mechanism for Nrf2 Pathway Activation in Human Cancers: L.D. Goldstein, et al.; Cell Rep. 16, 2605 (2016), Application(s): Cell Viability and DNA Fragmentation Analysis, Abstract
- Genetically encoded far-red fluorescent sensors for caspase-3 activity: O.A. Zlobovskaya, et al.; Biotechniques. 60, 62 (2016), Application(s): Induced apoptosis, Abstract — Full Text
- Targeting of nucleotide-binding proteins by HAMLET-a conserved tumor cell death mechanism: J.C. Ho, et al.; Oncogene 35, 897 (2016), Application(s): Cell Culture, Abstract
- Caspase-mediated cleavage of raptor participates in the inactivation of mTORC1 during cell death: Martin, R., Desponds, C., et al.; Cell Death Discov. 2, 16024 (2016), Abstract
- Inhibition of mTOR-kinase destabilizes MYCN and is a potential therapy for MYCN-dependent tumors: Vaughan, L., Clarke, P. A., et al.; Oncotarget 7, 57525 (2016), Abstract
- Artesunate induces apoptosis via a ROS-independent and Bax-mediated intrinsic pathway in HepG2 cells: G. Qin, et al.; Exp. Cell Res. 336, 308 (2015), Application(s): Cell Culture, Abstract
- A small molecule with anticancer and antimetastatic activities induces rapid mitochondrial associated necrosis in breast cancer: A. Bastian, et al.; J. Pharmacol. Exp. Ther. 353, 392 (2015), Application(s): Western Blotting, Abstract — Full Text
- The Wnt target protein Peter Pan defines a novel p53-independent nucleolar stress response pathway: A.S. Pfister, et al.; J. Biol. Chem. 290, 10905 (2015), Application(s): Cell Culture, Abstract — Full Text
- Chemoresistance is associated with increased cytoprotective autophagy and diminished apoptosis in bladder cancer cells treated with the BH3 mimetic (-)-Gossypol (AT-101).: J. Mani, et al.; BMC Cancer 15, 224 (2015), Application(s): Cell Culture, Abstract — Full Text
- Characterizing Cellular Biophysical Responses to Stress by Relating Density, Deformability, and Size: Byun, S., Hecht, V. C., et al.; Biophys. J. 109, 1565 (2015), Abstract
- Prolyl-4-hydroxylase domain 3 (PHD3) is a critical terminator for cell survival of macrophages under stress conditions: L. Swain, et al.; J. Leukoc. Biol. 96, 365 (2014), Abstract
- Docosahexanoic acid antagonizes TNF-α-induced necroptosis by attenuating oxidative stress, ceramide production, lysosomal dysfunction, and autophagic features: Pacheco, F. J., Almaguel, F. G., et al.; Inflamm. Res. 63, 859 (2014), Abstract
- Tannins from Hamamelis virginiana bark extract: characterization and improvement of the antiviral efficacy against influenza A virus and human papillomavirus: Theisen, L. L., Erdelmeier, C. A., et al.; PLoS One 9, e88062 (2014), Abstract
- Mechanism of dual specificity kinase activity of DYRK1A: A. Walte, et al.; FEBS J. 280, 4495 (2013), Application(s): HeLa cells, Abstract
- Matching biochemical and functional efficacies confirm ZIP as a potent competitive inhibitor of PKMζ in neurons: Yao, Y., Shao, C., et al.; Neuropharmacology 64, 37 (2013), Abstract
- Multiplicity-dependent activation of a serine protease-dependent cytomegalovirus-associated programmed cell death pathway: McCormick, A. L., Roback, L., et al.; Virology 435, 250 (2013), Abstract
- Noxa couples lysosomal membrane permeabilization and apoptosis during oxidative stress: Eno, C. O., Zhao, G., et al.; Free Radic. Biol. Med. 65, 26 (2013), Abstract
- Distinct roles of mitochondria- and ER-localized Bcl-xL in apoptosisresistance and Ca2+ homeostasis: C.O. Eno, et al.; Mol. Biol. Cell. 23, 2605 (2012), Abstract — Full Text
- Clostridium difficile Toxin B causes epithelial cell necrosis through an autoprocessing-independent mechanism: N.M. Chumbler, et al.; PLoS Pathog. 8, e1003072 (2012), Application(s): IHC, Abstract — Full Text
- Staurosporine and cytochalasin D induce chondrogenesis by regulation of actin dynamics in different way: M. Kim, et al.; Exp. Mol. Med. 44, 521 (2012), Abstract — Full Text
- A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/C: Mintzer, R., Ramaswamy, S., et al.; PLoS One 7, e30376 (2012), Abstract
- Bacillus anthracis lethal toxin reduces human alveolar epithelial barrier function: Langer, M., Duggan, E. S., et al.; Infect. Immun. 80, 4374 (2012), Abstract
- Curcumin attenuates staurosporine-mediated death of retinal ganglion cells: B. Burugula, et al.; Invest. Ophthalmol. Vis. Sci. 52, 4263 (2011), Abstract — Full Text
- FKBP51 protects 661w cell culture from staurosporine-induced apoptosis: D.R. Daudt & T. Yorio; Mol. Vis. 17, 1172 (2011), Abstract — Full Text
- Neuronal differentiation by analogs of staurosporine: A.F. Thompson & L.A. Levin; Neurochem. Int. 56, 554 (2010), Abstract — Full Text
- Caspases rather than calpains mediate remodelling of the fodrin skeleton during human placental trophoblast fusion: Gauster, M., Siwetz, M., et al.; Cell Death Differ. 17, 336 (2010), Abstract
- Single-cell analysis of dihydroartemisinin-induced apoptosis through reactive oxygen species-mediated caspase-8 activation and mitochondrial pathway in ASTC-a-1 cells using fluorescence imaging techniques: Lu, Y. Y., Chen, T. S., et al.; J. Biomed. Opt. 15, 046028 (2010), Abstract
- ALISSA: an automated live-cell imaging system for signal transduction analyses: Wenus, J., Düssmann, H., et al.; Biotechniques 47, 1033 (2009), Abstract
- Brain-derived neurotrophic factor released from engineered mesenchymal stem cells attenuates glutamate- and hydrogen peroxide-mediated death of staurosporine-differentiated RGC-5 cells: Harper, M. M., Adamson, L., et al.; Exp. Eye Res. 89, 538 (2009), Abstract
- Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin: Dormann, D., Capell, A., et al.; J. Neurochem. 110, 1082 (2009), Abstract
- Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells: Brachmann, S. M., Hofmann, I., et al.; PNAS 106, 22299 (2009), Abstract
- The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases: M. Rebsamen, et al.; Cell Death Differ. 15, 1804 (2008), Abstract
- The prevention of spontaneous apoptosis of follicular lymphoma B cells by a follicular dendritic cell line: involvement of caspase-3, caspase-8 and c-FLIP: J.J. Goval, et al.; Haematologica 93, 1169 (2008), Abstract — Full Text
- Differential production of superoxide by neuronal mitochondria: Hoegger, M. J., Lieven, C. J., et al.; BMC Neurosci. 9, 4 (2008), Abstract
- Mechanisms of retinal ganglion specific-cell death in Leber hereditary optic neuropathy: L.A. Levin; Trans. Am. Ophthalmol. Soc. 105, 379 (2008), Abstract
- Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002: M.D. Jacobs, et al.; J. Biol. Chem. 280, 13728 (2005), Abstract
- Enhancement of stress-induced apoptosis in B-lineage cells by caspase-9 inhibitor: Shah, N., Asch, R. J., et al.; Blood 104, 2873 (2004), Abstract
- Single-cell fluorescence resonance energy transfer analysis demonstrates that caspase activation during apoptosis is a rapid process. Role of caspase-3: M. Rehm, et al.; J. Biol. Chem. 277, 24506 (2002), Abstract — Full Text
- Insulin-stimulated protein kinase B phosphorylation on Ser-473 is independent of its activity and occurs through a staurosporine-insensitive kinase: M.M. Hill, et al.; J. Biol. Chem. 276, 25643 (2001), Abstract — Full Text
- Dissociation of staurosporine-induced apoptosis from G2-M arrest in SW620 human colonic carcinoma cells: initiation of the apoptotic cascade is associated with elevation of the mitochondrial membrane potential (deltapsim): B.G. Heerdt, et al.; Cancer Res. 60, 6704 (2000), Abstract
- Glycogen synthase kinase-3beta facilitates staurosporine- and heat shock-induced apoptosis. Protection by lithium: G.N. Bijur, et al.; J. Biol. Chem. 275, 7583 (2000), Abstract — Full Text
- Caspase-8 activation and bid cleavage contribute to MCF7 cellular execution in a caspase-3-dependent manner during staurosporine-mediated apoptosis: D. Tang, et al.; J. Biol. Chem. 275, 9303 (2000), Abstract — Full Text
- Changes in mitochondrial membrane potential during staurosporine- induced apoptosis in Jurkat cells: J.L. Scarlett, et al.; FEBS Lett. 475, 267 (2000), Abstract
- Molecular mechanism of staurosporine-induced apoptosis in osteoblasts: H.J. Chae, et al.; Pharmacol. Res. 42, 373 (2000), Abstract
- Equivalent death of P-glycoprotein expressing and nonexpressing cells induced by the protein kinase C inhibitor staurosporine: K.M. Tainton, et al.; BBRC 276, 231 (2000), Abstract
- Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c: D.G. Kirsch, et al.; J. Biol. Chem. 274, 21155 (1999), Abstract — Full Text
- Characterization of the cell death process induced by staurosporine in human neuroblastoma cell lines: J. Boix, et al.; Neuropharmacology 36, 811 (1997), Abstract
- Staurosporine and ent-staurosporine: the first total synthesis, prospects for a regioselective approach, and activity profile: J.T. Link et al.; J. Am. Chem. Soc. 118, 2825 (1996)
- K252a and staurosporine microbial alkaloid toxins as prototype of neurotropic drugs: P. Lazarovici, et al.; Adv. Exp. Med. Biol. 391, 367 (1996), Review, Abstract
- Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis: X. Wang et al.; EMBO J. 15, 1012 (1996), Abstract
- Mechanism of topoisomerase II inhibition by staurosporine and other protein kinase inhibitors: P. Lassota et al.; J. Biol. Chem. 271, 26418 (1996), Abstract
- Staurosporine induces programmed cell death in embryonic neurons and activation of the ceramide pathway: D.A. Wiesner & G. Dawson; J. Neurochem 66, 1418 (1996), Abstract
- First total synthesis of Staurosporine and ent-Staurosporine: J.T. Link et al.; J. Am. Chem. Soc. 117, 552 (1995)
- Differential inhibition of protein kinase C isozymes by UCN-01, a staurosporine analogue: C.M Seynaeve et al.; Mol. Pharmacol. 45, 1207 (1994), Abstract
- Induction of a common pathway of apoptosis by staurosporine: R. Bertrand, et al.; Exp. Cell Res. 211, 314 (1994), Abstract
- Staurosporine: an effective inhibitor for Ca2+/calmodulin-dependent protein kinase II: N. Yanagihara, et al.; J. Neurochem. 56, 294 (1991), Abstract
- Is staurosporine a specific inhibitor of protein kinase C in intact porcine coronary arteries?: M. Kageyama, et al.; J. Pharmacol. Exp. Ther. 259, 1019 (1991), Abstract
- Staurosporine, a protein kinase C inhibitor interferes with proliferation of arterial smooth muscle cells: H. Matsumoto & Y. Sasaki; Biochem. Biophys. Res. Commun. 158, 105 (1989), Abstract
- Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases: U.T. Ruegg & G.M. Burgess; TIPS 10, 218 (1989), (Review), Abstract
- Contrasting actions of staurosporine, a protein kinase C inhibitor, on human neutrophils and primary mouse epidermal cells: T. Sako, et al.; Cancer Res. 48, 4646 (1988), Abstract
- Staurosporine inhibits tyrosine-specific protein kinase activity of Rous sarcoma virus transforming protein p60: N. Nakano, et al.; J. Antibiot. (Tokyo) 40, 706 (1987), Abstract
- Staurosporine, a potent platelet aggregation inhibitor from a Streptomyces species: S. Oka, et al.; Agric. Biol. Chem. 50, 2723 (1986)
- Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase: T. Tamaoki, et al.; BBRC 135, 397 (1986), Abstract
- : A. Furusaki, et al.; J. C. S. Chem. Commun. , 800 (1978)
- A new alkaloid AM-2282 of Streptomyces origin. Taxonomy, fermentation, isolation and preliminary characterization: S. Omura, et al.; J. Antibiot. (Tokyo) 30, 275 (1977), Abstract
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| CAS | 120685-11-2 |
| Couple Type | Inhibitor |
| Purity | ≥98% (TLC) |
GFP-CERTIFIED® Apoptosis/Necrosis Detection kit
ENZ-51002
Multiplex assay that distinguishes between healthy, early apoptotic, late apoptotic and necrotic cells, compatible with GFP and other fluorescent probes (blue or cyan)
| Application | Flow Cytometry, Fluorescence microscopy, Fluorescent detection |
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| Source | Produced in insect cells. GST fusion proteins containing CDK2 (aa 1-298) and residues cyclin E (aa 1-394). Produced in a baculovirus expression system. |
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