Stattic

BML-EI368

Datasheet
Manual
SDS
CofA

Already have an account?

STAT inhibitor

Small molecule STAT3-specific inhibitor which blocks activation, dimerization and nuclear translocation via binding to the STAT3 SH2 domain. It is a very useful tool for exploring STAT3-mediated signaling pathways. It blocks LPS-mediated STAT3 tyrosine phosphorylation which leads to inhibition of LPS-mediated IL-1β and IL-6 production. In primary cultures of rat neural stem cells it blocks IL-15-induced differentiation.

Shipping: Available products typically ship within 24/48h, via priority shipping.

Do you need support? Contact Customer Service or Technical Support.

Online Account
Access or Create Your Account

Product Details

Alternative Name	6-Nitro[b]thiophene-1,1-dioxide
Appearance	Pale yellow solid.
CAS	19983-44-9
Couple Target	STAT
Couple Type	Inhibitor
Formula	C₈H₅NO₄S
MW	211.2
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (>25 mg/ml), 100% ethanol (10 mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store solutions at -20°C for up to 3 months.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

CREB Is Activated by the SCF/KIT Axis in a Partially ERK-Dependent Manner and Orchestrates Survival and the Induction of Immediate Early Genes in Human Skin Mast Cells: K. Franke, et al.; Int. J. Mol. Sci. 24, 4135 (2023), Abstract
Osmotic regulation of aquaporin-8 expression in retinal pigment epithelial cells in vitro: Dependence on KATP channel activation: B. Schnabel, et al.; Mol. Vis. 26, 797 (2020), Abstract
STAT3 Knockdown Induces Tumor Formation by MDA-MB-231 Cells: K. Banerjee, et al.; Clin. Oncol. Res. , (2018), Abstract — Full Text
Hypoxic expression of NLRP3 and VEGF in cultured retinal pigment epithelial cells: contribution of P2Y2 receptor signaling: F. Doktor, et al.; Purinergic Signal. 14, 471 (2018), Abstract
Osmotic regulation of NFAT5 expression in RPE cells: The involvement of purinergic receptor signaling: M. Hollborn, et al.; Mol. Vis. 23, 116 (2017), Abstract — Full Text
Regulation of the hyperosmotic induction of aquaporin 5 and VEGF in retinal pigment epithelial cells: involvement of NFAT5: M. Hollborn, et al.; Mol. Vis. 21, 360 (2015), Application(s): Cell Culture, Abstract — Full Text
Gene expression regulation in retinal pigment epithelial cells induced by viral RNA and viral/bacterial DNA: A. Brosig, et al.; Mol. Vis. 21, 1000 (2015), Application(s): Cell Culture, Abstract — Full Text
STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteria: L. Samavati, et al.; Mol. Immunol. 46, 1867 (2009), Abstract
Effects of interleukin-15 on neuronal differentiation of neural stem cells: Y.S. Huang, et al.; Brain Res. 1304, 38 (2009), Abstract
Stattic: a small-molecule inhibitor of STAT3 activation and dimerization: J. Schust, et al.; Chem. Biol. 13, 1235 (2006), Abstract

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Datasheet

Certificate of Analysis

Please enter the lot number as featured on the product label

Lot No. :

SDS

Enzo Life Science provides GHS Compliant SDS

English (EU) SDS

If your language is not available please fill out the SDS request form

Your Cart

Your Cart

Stattic

BML-EI368

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

Change Country

Tell us about You

Tell us about your paper

Tell us about You

Tell us about your project