STA-21

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STAT inhibitor

STA-21 is a novel Stat3-selective inhibitor. It inhibits Stat3 dimerization and DNA binding as well as Stat3-dependent luciferase reporter activity.

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Alternative Name	(S)-Ochromycinone, Deoxytetrangomycin
Appearance	White to yellow solid.
CAS	28882-53-3
Couple Target	STAT
Couple Type	Inhibitor
Formula	C₁₉H₁₄O₄
MW	306.3
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (20mg/ml).

Use/Stability	As indicated on product label or CoA when stored as recommended. Store solutions at -20°C for up to 3 months.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

IL-21-Induced MHC Class II+ NK Cells Promote the Expansion of Human Uncommitted CD4+ Central Memory T Cells in a Macrophage Migration Inhibitory Factor-Dependent Manner: Loyon, R., Picard, E., et al.; J. Immunol. 197, 85 (2016), Abstract
An endoplasmic reticulum stress-initiated sphingolipid metabolite, ceramide-1-phosphate, regulates epithelial innate immunity by stimulating β-defensin production: Kim, Y. I., Park, K., et al.; Mol. Cell. Biol. 34, 4368 (2014), Abstract
Malignant cutaneous T-cell lymphoma cells express IL-17 utilizing the Jak3/Stat3 signaling pathway: Krejsgaard, T., Ralfkiaer, U., et al.; J. Invest. Dermatol. 131, 1331 (2011), Abstract
A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells: H. Song, et al.; PNAS USA 102, 4700 (2005), Abstract

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