Src I1

BML-EI398

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Inhibitor of Src kinase and p56lck tyrosine kinase

Potent, dual site (ATP domain and substrate-binding domain) Src and Lck kinase inhibitor (IC₅₀=44 and 88nM respectively). VEGFR2 IC₅₀=0.32μM; c-fms IC₅₀=30μM.

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Product Details

Alternative Name	6,7-Dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine
Appearance	Off-white solid.
CAS	179248-59-0
Couple Target	p56lck tyrosine kinase, Src kinase
Couple Type	Inhibitor
Formula	C₂₂H₁₉N₃O₃
MW	373.4
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (5mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

c-Src tyrosine kinase mediates high glucose-induced endothelin-1 expression: S.A. Manea, et al.; Int. J. Biochem. Cell Biol. 75, 123 (2016), Application(s): Cell culture, Abstract
High basal Wnt signaling is further induced by PI3K/mTor inhibition but sensitive to cSRC inhibition in mammary carcinoma cell lines with HER2/3 overexpression: Timmermans-Sprang, E. P., Gracanin, A., et al.; BMC Cancer 15, 545 (2015), Abstract
The selectivity of protein kinase inhibitors: a further update: J. Bain, et al.; Biochem. J. 408, 297 (2007), Abstract
Structural determinants for potent, selective dual site inhibition of human pp60c-src by 4-anilinoquinazolines: G. Tian, et al.; Biochemistry 40, 7084 (2001), Abstract

Last modified: May 29, 2024

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Src I1

BML-EI398

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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