SQ 22536

BML-CN140

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Adenylate cyclase inhibitor

SQ 22536 is a cell-permeable adenylate cyclase inhibitor. It inhibits cAMP production induced by prostaglandin E₁ in platelet lysates (IC₅₀=82 µM) and in intact platelets (IC₅₀=1 µM). It has been successfully employed as a probe for the involvement of adenylate cyclase in a variety of receptor systems including those for prostaglandins and neurotransmitters. ReducesPGE₂-induced inhibition of O₂– production.

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Product Details

Alternative Name	9-THF-Ade
Appearance	White to off-white solid.
CAS	17318-31-9
Couple Target	Adenylate cyclase
Couple Type	Inhibitor
Formula	C₉H₁₁N₅O
MW	205.2
Purity	≥99% (TLC)
Solubility	Soluble in water (25mg/ml) or DMSO (50mM with warming).
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Olfactory signaling components and olfactory receptors are expressed in tubule cells of the human kidney: B. Kalbe, et al.; Arch. Biochem. Biophys. 610, 8 (2016), Application(s): Calcium imaging, HK-2 cells, Abstract
Olfactory Receptors Modulate Physiological Processes in Human Airway Smooth Muscle Cells: Kalbe, B., Knobloch, J., et al.; Front. Physiol. 7, 339 (2016), Abstract
Hydrogen peroxide stimulation of CFTR reveals an Epac-mediated, soluble AC-dependent cAMP amplification pathway common to GPCR signalling: P. Ivonnet, et al.; Br. J. Pharmacol. 172, 173 (2015), Abstract — Full Text
Vasodilation by GPER in mesenteric arteries involves both endothelial nitric oxide and smooth muscle cAMP signaling: Lindsey, S. H., Liu, L., et al.; Steroids 81, 99 (2014), Abstract
IL-6, A1 and A2aR: a crosstalk that modulates BDNF and induces neuroprotection: Perígolo-Vicente, R., Ritt, K., et al.; Biochem. Biophys. Res. Commun. 449, 477 (2014), Abstract
From blue light to clock genes in zebrafish ZEM-2S cells: Ramos, B. C., Moraes, M. N., et al.; PLoS One 9, e106252 (2014), Application(s): In Vitro, Abstract
Characteristics of the actions by which 5-HT affects electrical and mechanical activities in rabbit jugular vein: Itoh, T., Kajikuri, J., et al.; Br. J. Pharmacol. 164, 979 (2011), Abstract
Neurotrophic effect of citrus 5-hydroxy-3,6,7,8,3′,4′-hexamethoxyflavone: promotion of neurite outgrowth via cAMP/PKA/CREB pathway in PC12 cells: Lai, H. C., Wu, M. J., et al.; PLoS One 6, e28280 (2011), Abstract
Regulation of store-operated calcium entry by calcium-independent phospholipase A2 in rat cerebellar astrocytes: Singaravelu, K., Lohr, C., et al.; J. Neurosci. 26, 9579 (2006), Abstract
Characterization of the PGE receptor subtype mediating inhibition of superoxide production in human neutrophils: E. Talpain et al.; Br. J. Pharmacol. 114, 1459 (1995), Abstract

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SQ 22536

BML-CN140

Product Details

Handling & Storage

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