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Sphingomyelinase (Staphylococcus aureus)

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Alternative Name	Sphingomyelin cholinephosphohydrolase
Application Notes	May be used exogenously to initiate the sphingomyelin signaling pathway. Has very little activity on phosphatidylcholine.
CAS	9031-54-3
Formulation	Liquid. Supplied in 50% glycerol/0.25 M phosphate buffer.
Source	Isolated from Staphylococcus aureus.
Specific Activity	Specific activity: 100-300 U/mg protein. One unit will hydrolyze 1 µmol of TNPAL-sphingomyelin per minute at pH 7.4 and 37°C
UniProt ID	P09978

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	+4°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Multimodal imaging of synaptic vesicles with a single probe: An, S. J., Stagi, M., et al.; Cell Rep. Methods 2, 100199 (2022), Abstract
Acid sphingomyelinase promotes SGK1-dependent vascular calcification: T. Luong, et al.; Clin. Sci. 135, 515 (2021), Abstract — Full Text
Depletion of Host and Viral Sphingomyelin Impairs Influenza Virus Infection: Audi, A., Soudani, N., et al.; Front. Microbiol. 11, 612 (2020), Abstract

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