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Sparfloxacin

ALX-380-302

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Fluoroquinolone antibacterial agent

Fluoroquinolone with broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Inhibits bacterial DNA gyrase (topoisomerase). Effective against Mycobacterium tuberculosis. Shows photosensitizing effects.

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Product Details

Alternative Name	rel-5-Amino-1-cyclopropyl-7-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, AT-4140
Appearance	White to yellow crystalline solid.
CAS	110871-86-8
Couple Target	DNA gyrase
Couple Type	Inhibitor
Formula	C₁₉H₂₂F₂N₄O₃
Identity	Determined by IR.
MI	14: 8735
MW	392.4
Purity	≥98% (Assay)
RTECS	VB1986500
Solubility	Soluble in 100% ethanol or water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Moxifloxacin, ofloxacin, sparfloxacin, and ciprofloxacin against Mycobacterium tuberculosis: evaluation of in vitro and pharmacodynamic indices that best predict in vivo efficacy: R.K. Shandil, et al.; Antimicrob. Agents Chemother. 51, 576 (2007), Abstract — Full Text
The link between sunshine and phototoxicity of sparfloxacin: C. Pierfitte, et al.; Br. J. Clin. Pharmacol. 49, 609 (2000), Abstract — Full Text
Sparfloxacin: a review: J.J. Schentag; Clin. Ther. 22, 372 (2000), (Review), Abstract
Mechanism of action of sparfloxacin against and mechanism of resistance in gram-negative and gram-positive bacteria: L.J. Piddock & M. Zhu; Antimicrob. Agents Chemother. 35, 2423 (1991), Abstract — Full Text
Synthesis and structure-activity relationships of 5-substituted 6,8-difluoroquinolones, including sparfloxacin, a new quinolone antibacterial agent with improved potency: T. Miyamoto, et al.; J. Med. Chem. 33, 1645 (1990), Abstract
Pharmacokinetics of a novel quinolone, AT-4140, in animals: S. Nakamura, et al.; Antimicrob. Agents Chemother. 34, 89 (1990), Abstract — Full Text
In vitro and in vivo antibacterial activities of AT-4140, a new broad-spectrum quinolone: S. Nakamura, et al.; Antimicrob. Agents Chemother. 33, 1167 (1989), Abstract — Full Text

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Sparfloxacin

ALX-380-302

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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