AMPIVIEW® RNA probes
Enabling Your Projects 
GMP Services
Bulk Solutions
Research Travel Grant
Have You Published Using an Enzo Product?
Jnk inhibitor
Potent, cell permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50=40nM for JNK-1 and JNK-2 and 90nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38. Inhibits the phosphorylation of c-Jun and blocks the expression of IL-2, IFN-γ, TNF-α, and COX-2. Blocks IL-1-induced accumulation of phospho-Jun, induction of c-Jun transcription and anti CD3-induced apoptosis of CD4+ CD8+ thymocytes.
Shipping: Available products typically ship within 24/48h, via priority shipping.
Do you need support? Contact Customer Service or Technical Support.
Online Account
Access or Create Your Account
Product Details
| Alternative Name |
Anthra(1,9-cd)pyrazol-6(2H)-one, 1,9-Pyrazoloanthrone |
|---|---|
| Appearance |
Yellow to brown solid. |
| CAS |
129-56-6 |
| Couple Target |
Jnk |
| Couple Type |
Inhibitor |
| Formula |
C14H8N2O |
| MW |
220.2 |
| Purity |
≥98% (TLC) |
| RTECS |
CB4585000 |
| Solubility |
Soluble in DMSO or methanol. |
| Technical Info / Product Notes |
Note: Product is not sterile. |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored at +20°C. Stock solutions are stable for up to 3 months at -20°C. |
|---|---|
| Handling |
Protect from light. Keep under inert gas. |
| Long Term Storage |
Ambient |
| Shipping |
Ambient Temperature |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Fibrosis factor CTGF facilitates VCAM‑1‑dependent monocyte adhesion to osteoarthritis synovial fibroblasts via the FAK and JNK pathways: Liu, S. C., Law, Y. Y., et al.; Mol. Med. Rep. 31, 124 (2025), Abstract
- Fraxetin reduces endometriotic lesions through activation of ER stress, induction of mitochondria-mediated apoptosis, and generation of ROS: J. Ham, et al.; Phytomedicine 123, 155187 (2024), Abstract
- Picolinafen exposure induces ROS accumulation and calcium depletion, leading to apoptosis in porcine embryonic trophectoderm and uterine luminal epithelial cells: W. Park, et al.; Theriogenology 201, 12 (2023), Abstract
- CREB Is Activated by the SCF/KIT Axis in a Partially ERK-Dependent Manner and Orchestrates Survival and the Induction of Immediate Early Genes in Human Skin Mast Cells: K. Franke, et al.; Int. J. Mol. Sci. 24, 4135 (2023), Abstract
- Aclonifen induces bovine mammary gland epithelial cell death by disrupting calcium homeostasis and inducing ROS production: J. Park, et al.; Pestic. Biochem. Physiol. 181, 105011 (2022), Abstract
- Exosomal p38 Mitogen-activated Protein Kinase Promotes Tumour Repopulation in TP53-mutated Bile Duct Cancer Cells: M. Osawa, et al.; Anticancer Res. 42, 745 (2022), Abstract
- Hepatocyte Bcl-3 protects from death-receptor mediated apoptosis and subsequent acute liver failure: N. Gehrke, et al.; Cell Death Dis. 13, 510 (2022), Abstract
- Inhibition of thymic stromal lymphopoietin production by FK3453: R. Segawa, et al.; J. Pharmacol. Sci. 149, 198 (2022), Abstract
- Effect of Antioxidants on the Production of MCP-1 Chemokine by EA. hy926 Cells in Response to IL-6: M.A. Chelombitko, et al.; Moscow Univ. Biol. Sci. Bull. 77, 184 (2022), Abstract
- Fluroxypyr-1-methylheptyl ester causes apoptosis of bovine mammary gland epithelial cells by regulating PI3K and MAPK signaling pathways and endoplasmic reticulum stress: G. Am, et al.; Pestic. Biochem. Physiol. 180, 105003 (2021), Abstract
- Signalling Pathways Mediating the Effects of CD40-Activated CD40L Reverse Signalling on Inhibitory Medium Spiny Neuron Neurite Growth: Carriba, P., Davies, A. M., et al.; Cells 10, (2021), Abstract
- How CD40L Reverse Signaling Regulates Axon and Dendrite Growth: P. Carriba & A.M. Davies; Cell. Mol. Life Sci. 78, 1065 (2021), Abstract — Full Text
- FJU-C28 inhibits the endotoxin-induced pro-inflammatory cytokines expression via suppressing JNK, p38 MAPK and NF-κB signaling pathways: F. Jung, et al.; Pharmacol. Res. Perspect. 9, e00876 (2021), Abstract
- Effects of S-PRG filler eluate on MMP-1 and MMP-3 secretion by human gingival fibroblasts: H. Inoue, et al.; Dent. Mater. J. , (2021), Abstract
- Methylglyoxal attenuates isoproterenol-induced increase in uncoupling protein 1 expression through activation of JNK signaling pathway in beige adipocytes: S.P. Ng, et al.; Biochem. Biophys. Rep. 28, 101127 (2021), Abstract
- Diflubenzuron leads to apoptotic cell death through ROS generation and mitochondrial dysfunction in bovine mammary epithelial cells: W. Lee, et al.; Pestic. Biochem. Physiol. 177, 104893 (2021), Abstract
- Exposure to fipronil induces cell cycle arrest, DNA damage, and apoptosis in porcine trophectoderm and endometrial epithelium, leading to implantation defects during early pregnancy: W. Park, et al.; Environ. Pollut. 291, 118234 (2021), Abstract
- JNK signaling is required for proper tangential migration and laminar allocation of cortical interneurons: Myers, A. K., Cunningham, J. G., et al.; Development 147, (2020), Abstract
- JNK Signaling Regulates Cellular Mechanics of Cortical Interneuron Migration: Smith, S. E., Coker, N. K., et al.; eNeuro 7, (2020), Abstract
- Luteolin Attenuates IL-1 β-Induced THP-1 Adhesion to ARPE-19 Cells via Suppression of NF- κ B and MAPK Pathways: W. Huang, et al.; Mediators Inflamm. 2020, 9421340 (2020), Abstract — Full Text
- Induction of Lysosomal Membrane Permeabilization Is a Major Event of FTY720-Mediated Non-Apoptotic Cell Death in Human Glioma Cells: K. Min, et al.; Cancers (Basel) 12, 3388 (2020), Abstract — Full Text
- The DsbA-L gene is associated with respiratory function of the elderly via its adiponectin multimeric or antioxidant properties: K. Oniki, et al.; Sci. Rep. 10, 5973 (2020), Abstract — Full Text
- Nobiletin Promotes Megakaryocytic Differentiation through the MAPK/ERK-Dependent EGR1 Expression and Exerts Anti-Leukemic Effects in Human Chronic Myeloid Leukemia (CML) K562 Cells: J.H. Yen, et al.; Cells 9, 877 (2020), Abstract — Full Text
- Regulators of thymic stromal lymphopoietin production by human adipocytes: L. Ma, et al.; Cytokine 136, 155284 (2020), Application(s): Treatment of preadipocytes in culture supernatant, Abstract
- Quercetin augments apoptosis of canine osteosarcoma cells by disrupting mitochondria membrane potential and regulating PKB and MAPK signal transduction: S. Ryu, et al.; J. Cell. Biochem. 120, 17449 (2019), Abstract
- Anti-inflammatory effects of mesenchymal stem cell-derived exosomal microRNA-146a-5p and microRNA-548e-5p on human trophoblast cells: C. Yang, et al.; Mol. Hum. Reprod. 25, 755 (2019), Abstract
- Nemo-like kinase drives Foxp3 stability and is critical for maintenance of immune tolerance by regulatory T cells: V. Fleskens, et al.; Cell Rep. 26, 3600 (2019), Abstract — Full Text
- Rapid induction of p62 and GABARAPL1 upon proteasome inhibition promotes survival before autophagy activation: Sha, Z., Schnell, H. M., et al.; J. Cell Biol. 217, 1757 (2018), Abstract
- Chrysin attenuates progression of ovarian cancer cells by regulating signaling cascades and mitochondrial dysfunction: W. Lim, et al.; J. Cell. Physiol. 233, 3129 (2018), Abstract
- Fibroblast growth factor 2 induces proliferation and distribution of G2 /M phase of bovine endometrial cells involving activation of PI3K/AKT and MAPK cell signaling and prevention of effects of ER stress: W. Lim, et al.; J. Cell. Physiol. 233, 3295 (2018), Abstract
- Carbon monoxide releasing molecule-2 attenuates Pseudomonas aeruginosa-induced ROS-dependent ICAM-1 expression in human pulmonary alveolar epithelial cells: C.W. Lee, et al.; Redox Biol. 18, 93 (2018), Abstract — Full Text
- PRMT1 mediates RANKL-induced osteoclastogenesis and contributes to bone loss in ovariectomized mice: J.H. Choi, et al.; Exp. Mol. Med. 50, 111 (2018), Abstract
- Sideroxylin (Callistemon lanceolatus) suppressed cell proliferation and increased apoptosis in ovarian cancer cells accompanied by mitochondrialdysfunction, the generation of reactive oxygen species, and an increase of lipid peroxidation: S. Park, et al.; J. Cell. Physiol. 233, 8597 (2018), Application(s): Treatment of ovarian cancer cells (ES2 and OV90), Abstract
- A redox state-dictated signalling pathway deciphers the malignant cell specificity of CD40-mediated apoptosis: Dunnill, C. J., Ibraheem, K., et al.; Oncogene 36, 2515 (2017), Abstract
- Differential expression and functional roles of chemokine (C-C motif) ligand 23 and its receptor chemokine (C-C motif) receptor type 1 in the uterine endometrium during early pregnancy in pigs: W. Jeong, et al.; Dev. Comp. Immunol. 76, 316 (2017), Abstract
- N-n-butyl Haloperidol Iodide Protects against Hypoxia/Reoxygenation Injury in Cardiac Microvascular Endothelial Cells by Regulating the ROS/MAPK/Egr-1 Pathway: Lu, S., Zhang, Y., et al.; Front. Pharmacol. 7, 520 (2017), Abstract
- Myricetin suppresses invasion and promotes cell death in human placental choriocarcinoma cells through induction of oxidative stress: C. Yang, et al.; Cancer Lett. 399, 10 (2017), Abstract
- Gomisin N Decreases Inflammatory Cytokine Production in Human Periodontal Ligament Cells: Y. Hosokawa, et al.; Inflammation 40, 360 (2017), Abstract
- Endogenous AMPK acts as a detrimental factor in fulminant hepatitis via potentiating JNK-dependent hepatocyte apoptosis: K. Hu, et al.; Cell Death Dis. 8, e2637 (2017), Abstract — Full Text
- Ceramide Induces Human Hepcidin Gene Transcription through JAK/STAT3 Pathway: Lu, S., Natarajan, S. K., et al.; PLoS One 11, e0147474 (2016), Abstract
- Hypotonic Stress-Induced Down-Regulation of Claudin-1 and -2 Mediated by Dephosphorylation and Clathrin-Dependent Endocytosis in Renal Tubular Epithelial Cells: N. Fujii, et al.; J. Biol. Chem. 291, 24787 (2016), Application(s):, Abstract — Full Text
- Tunicamycin-induced Endoplasmic Reticulum Stress Upregulates the Expression of Pentraxin 3 in Human Retinal Pigment Epithelial Cells: N. Hwang, et al.; Korean J. Ophthalmol. 30, 468 (2016), Abstract — Full Text
- Eupafolin nanoparticles protect HaCaT keratinocytes from particulate matter-induced inflammation and oxidative stress: Z.C. Lin, et al.; Int. J. Nanomedicine 11, 2907 (2016), Application(s): Cell treatment to see effect on PM-induced phosphorylation, Abstract — Full Text
- Activation of autophagy by FOXO3 regulates redox homeostasis during osteogenic differentiation: M.C. Gómez-Puerto, et al.; Autophagy 12, 1804 (2016), Abstract — Full Text
- NORE1A induction by membrane-bound CD40L (mCD40L) contributes to CD40L-induced cell death and G1 growth arrest in p21-mediated mechanism: T. Elmetwali, et al.; Cell Death Dis. 7, e2146 (2016), Application(s): Cell culture, Abstract
- Calcitonin gene-related peptide is a key factor in the homing of transplanted human MSCs to sites of spinal cord injury: Y. Zhang, et al.; Sci. Rep. 6, 27724 (2016), Application(s): Migration assay in Boyden chamber, Abstract — Full Text
- Phloretin ameliorates chemokines and ICAM-1 expression via blocking of the NF-κB pathway in the TNF-α-induced HaCaT human keratinocytes: W.C. Huang, et al.; Int. Immunopharmacol. 27, 32 (2015), Application(s): Cell Culture, Western Blot, Abstract
- Andrographolide decreased VEGFD expression in hepatoma cancer cells by inducing ubiquitin/proteasome-mediated cFos protein degradation: L. Ji, et al.; Biochim. Biophys. Acta. 1850, 750 (2015), Application(s): Cell Culture, Abstract
- Involvement of JNK and Caspase Activation in Hoiamide A-Induced Neurotoxicity in Neocortical Neurons: Z. Cao, et al.; Mar. Drugs 13, 903 (2015), Application(s): Cell Culture, Abstract — Full Text
- Involvement of p38 MAPK activation mediated through AT1 receptors on spinal astrocytes and neurons in angiotensin II- and III-induced nociceptive behavior in mice: W. Nemoto, et al.; Neuropharmacology 99, 221 (2015), Application(s): Injection into mice, Abstract
- Suppression of death receptor 5 enhances cancer cell invasion and metastasis through activation of caspase-8/TRAF2-mediated signaling: Y.T. Oh, et al.; Oncotarget 6, 41324 (2015), Application(s): Cell culture , Abstract — Full Text
- Amphiregulin may be a new biomarker of classically activated macrophages: C. Meng, et al.; Biochem. Biophys. Res. Commun. 466, 393 (2015), Application(s): Cell Culture, Abstract
- Glycated albumin triggers fibrosis and apoptosis via an NADPH oxidase/Nox4-MAPK pathway-dependent mechanism in renal proximal tubular cells: W. Qi, et al.; Mol. Cell. Endocrinol. 405, 74 (2015), Application(s): Cell Culture, Abstract
- CArG-driven GADD45α activated by resveratrol inhibits lung cancer cells: Q. Shi, et al.; Genes Cancer 6, 220 (2015), Application(s): Cell Culture, Abstract — Full Text
- Infection with Leishmania major induces a cellular stress response in macrophages: Filardy, A. A., Costa-da-Silva, A. C., et al.; PLoS One 9, e85715 (2014), Abstract
- Valproic acid overcomes transforming growth factor-β-mediated sorafenib resistance in hepatocellular carcinoma: Matsuda, Y., Wakai, T., et al.; Int. J. Clin. Exp. Pathol. 7, 1299 (2014), Abstract
- Suppression of MAPK/JNK-MTORC1 signaling leads to premature loss of organelles and nuclei by autophagy during terminal differentiation of lens fiber cells: Basu, S., Rajakaruna, S., et al.; Autophagy 10, 1193 (2014), Abstract
- PP2A inhibitors suppress migration and growth of PANC-1 pancreatic cancer cells through inhibition on the Wnt/β-catenin pathway by phosphorylation and degradation of β-catenin: M.Y. Wu, et al.; Oncol Rep. 32, 513 (2014), Abstract — Full Text
- Expression profile of cord blood neutrophils and dysregulation of HSPA1A and OLR1 upon challenge by bacterial peptidoglycan: Fong, O. N., Chan, K. Y., et al.; J. Leukoc. Biol. 95, 169 (2014), Abstract
- Elastase induces lung epithelial cell autophagy through placental growth factor: a new insight of emphysema pathogenesis: Hou, H. H., Cheng, S. L., et al.; Autophagy 10, 1509 (2014), Abstract
- Cortical interneurons require Jnk1 to enter and navigate the developing cerebral cortex: Myers, A. K., Meechan, D. W., et al.; J. Neurosci. 34, 7787 (2014), Abstract
- Restoring KLF5 in esophageal squamous cell cancer cells activates the JNK pathway leading to apoptosis and reduced cell survival: Tarapore, R. S., Yang, Y., et al.; Neoplasia 15, 472 (2013), Abstract
- Caspase-2 and JNK activated by saturated fatty acids are not involved in apoptosis induction but modulate ER stress in human pancreatic β-cells: Nĕmcová-Fürstová, V., Balusikova, K., et al.; Cell. Physiol. Biochem. 31, 277 (2013), Abstract
- TR3 modulates platinum resistance in ovarian cancer: Wilson, A. J., Liu, A. Y., et al.; Cancer Res. 73, 4758 (2013), Abstract
- Differential p38-dependent signalling in response to cellular stress and mitogenic stimulation in fibroblasts: Faust, D., Schmitt, C., et al.; Cell Commun. Signal. 10, 6 (2012), Abstract
- Involvement of the RNA-binding protein ARE/poly(U)-binding factor 1 (AUF1) in the cytotoxic effects of proinflammatory cytokines on pancreatic beta cells: E. Roggli, et al.; Diabetologia 55, 1699 (2012), Application(s): Treatment of pancreatic beta cells, Abstract
- The ω-3 epoxide of eicosapentaenoic acid inhibits endothelial cell proliferation by p38 MAP kinase activation and cyclin D1/CDK4 down-regulation: Cui, P. H., Petrovic, N., et al.; Br. J. Pharmacol. 162, 1143 (2011), Abstract
- RASSF7 negatively regulates pro-apoptotic JNK signaling by inhibiting the activity of phosphorylated-MKK7: Takahashi, S., Ebihara, A., et al.; Cell Death Differ. 18, 645 (2011), Abstract
- Malignant cutaneous T-cell lymphoma cells express IL-17 utilizing the Jak3/Stat3 signaling pathway: Krejsgaard, T., Ralfkiaer, U., et al.; J. Invest. Dermatol. 131, 1331 (2011), Abstract
- CpG Protects Human Monocytic Cells against HIV-Vpr-Induced Apoptosis by Cellular Inhibitor of Apoptosis-2 through the Calcium-Activated JNK Pathway in a TLR9-Independent Manner: M. Saxena, et al.; J. Immunol. 187, 5865 (2011), Application(s): WB of human monocytes, Abstract — Full Text
- CD40 ligand-induced carcinoma cell death: a balance between activation of TNFR-associated factor (TRAF) 3-dependent death signals and suppression of TRAF6-dependent survival signals: Elmetwali, T., Young, L. S., et al.; J. Immunol. 184, 1111 (2010), Abstract
- Thapsigargin induces expression of activating transcription factor 3 in human keratinocytes involving Ca2+ ions and c-Jun N-terminal protein kinase: Spohn, D., Rössler, O. G., et al.; Mol. Pharmacol. 78, 865 (2010), Abstract
- Inhibition of basal p38 or JNK activity enhances epithelial barrier function through differential modulation of claudin expression: Carrozzino, F., Pugnale, P., et al.; Am. J. Physiol. Cell Physiol. 297, C775 (2009), Abstract
- Ceramide activates JNK to inhibit a cAMP-gated K+ conductance and Cl- secretion in intestinal epithelia: Saslowsky, D. E., Tanaka, N., et al.; FASEB J. 23, 259 (2009), Abstract
- Mechanism and Repertoire of ASC-Mediated Gene Expression: M. Hasegawa, et al.; J. Immunol. 182, 7655 (2009), Abstract
- Inhibition of N-(4-hydroxyphenyl)retinamide-induced autophagy at a lower dose enhances cell death in malignant glioma cells: Tiwari, M., Bajpai, V. K., et al.; Carcinogenesis 29, 600 (2008), Abstract
- Manganese chloride stimulates rat microglia to release hydrogen peroxide: Zhang, P., Hatter, A., et al.; Toxicol. Lett. 173, 88 (2007), Abstract
- Role of receptor for advanced glycation end-products and signalling events in advanced glycation end-product-induced monocyte chemoattractant protein-1 expression in differentiated mouse podocytes: Gu, L., Hagiwara, S., et al.; Nephrol. Dial. Transplant. 21, 299 (2006), Abstract
- Inhibition of c-Jun NH2-terminal kinase activity improves ischemia/reperfusion injury in rat lungs: M. Ishii, et al.; J. Immunol. 172, 2569 (2004), Abstract
- An inhibitor of c-jun aminoterminal kinase (SP600125) represses c-Jun activation, DNA-binding and PMA-inducible 92-kDa type IV collagenase expression: M. Shin, et al.; Biochim. Biophys. Acta 1589, 311 (2002), Abstract
- TAK1/JNK and p38 have opposite effects on rat hepatic stellate cells: B. Schnabl, et al.; Hepatology 34, 953 (2001), Abstract
- c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis: Z. Han, et al.; J. Clin. Invest. 108, 73 (2001), Abstract — Full Text
- SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase: B.L. Bennett, et al.; PNAS 98, 13681 (2001), Abstract — Full Text
- Role of JNK in hypertonic activation of Cl(-)-dependent Na(+)/H(+) exchange in Xenopus oocytes: G.G. Goss, et al.; Am. J. Physiol. Cell. Physiol. 281, C1978 (2001), Abstract
Datasheet, Manuals, SDS & CofA
Manuals And Inserts
Certificate of Analysis
Please enter the lot number as featured on the product label
SDS
Enzo Life Science provides GHS Compliant SDS
If your language is not available please fill out the SDS request form