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Sp-5,6-Dichloro-cBIMPS

BML-CN120

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PKA activator

A cAMP analog which is a potent and specific activator of cAMP-dependent protein kinase. It is cell permeable and is not significantly hydrolyzed by type I, II or III phosphodiesterases. It may be used to distinguish the cAMP- versus the cGMP-mediated signal transduction pathways. Surpasses the widely used but problematic dibutyryl-cAMP (Prod. No. BML-CN125) or 8-CPT-cAMP (Prod. No. BML-CN130).

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Product Details

Appearance	White solid.
CAS	120912-54-1
Couple Target	PKA
Couple Type	Activator
Formula	C₁₂H₁₀N₂O₅PSCl₂ . Na
MW	419.2
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (167 mM), dimethyl formamide (167 mM), 96 % ethanol (167 mM), methanol (25 mM), water (25 mM) and aqueous buffers such as phostphate buffered saline (pH 7.4; 1.4 mM), 25 mM TRIS (pH 7.4-; 25 mM), 25 mM HEPES (pH 7.2; 35.7 mM) or Na2HPO4.
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Comparative characteristics between calyculin A-induced and thimerosal-induced hyperactivation of cryopreserved bovine spermatozoa: N. Miyamoto, et al.; J. Reprod. Dev. 69, 170 (2023), Abstract
Changes of IZUMO1 in bull spermatozoa during the maturation, acrosome reaction and cryopreservation: M. Fukuda, et al.; Theriogenology 86, 2179 (2016), Application(s): Treatments for induction of the acrosome reaction, Abstract
Involvement of cyclic AMP-dependent unique signaling cascades in the decrease of serine/threonine-phosphorylated proteins in boar sperm head: A. Isono, et al.; Theriogenology 85, 1152 (2016), Application(s): Incubation of spermatozoa for induction of acrosome reaction, Abstract
Cell-permeable non-hydrolyzable cAMP derivatives as tools for analysis of signaling pathways controlling gene regulation in Dictyostelium: P. Schaap et al.; J. Biol. Chem. 268, 6323 (1993), Abstract
Characterization of Sp-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole- 3′,5′-monophosphorothioate (Sp-5,6-DCl-cBiMPS) as a potent and specific activator of cyclic-AMP-dependent protein kinase in cell extracts and intact cells: M. Sandberg et al.; Biochem. J. 279 ( Pt 2), 521 (1991), Abstract

Related Products

Dibutyryl-cAMP

BML-CN125

PKA activator

19 citations

Alternative Name	Dibutyl cyclic AMP sodium salt, N6-2′-O-dibutyryladenosine-3′,5′-cyclic monophosphate, DB-cAMP
CAS	16980-89-5
Couple Type	Activator
Purity	≥98% (HPLC)

8-CPT-cAMP

BML-CN130

PKA activator

13 citations

CAS	93882-12-3
Couple Type	Activator
Purity	≥96% (HPLC)

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Sp-5,6-Dichloro-cBIMPS

BML-CN120

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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Certificate of Analysis

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