Sp-5,6-DCl-cBIMPS

Potent, specific and site selective activator of cAMP- dependent protein kinases especially suitable for intact cells showing preference for site B of type II isozyme. Completely stable against mammalian cPDE types I & III and only extremely slowly hydrolized by cPDE type II. Surpasses the widely used but problematic dibutyryl cAMP or 8-CPT-cAMP in terms of metabolic stability, membrane permeability and potency. The corresponding Rp- isomer is available as well (Prod. No. BLG-D013).