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SH3 binding sequence of guanine nucleotide exchange factor hSOS which is a ligand for the adaptor protein Grb2 SH3 domain. Blocks SOS/Grb2 interaction and thereby prevents Ras activation via receptor protein tyrosine kinases. Km=5.6 µM for N-terminal SH3 of Grb2.
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RUO – Research Use Only |
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