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Since the discovery of somatostatin-14 (SOM-14) in ovine hypothalamus, several other forms of somatostatin-like immunoreactants of different molecular weight have been reported, including somatostatin-28 which expresses the full SOM-14 sequence at its C-terminus (SOM-28[15-28]). In mammals both molecular forms are encoded at the C-terminus of the somatostatin precursor molecule. Hundreds of immunolocalisation studies have been published demonstrating the existence of somatostatin-like molecules in neurons, in pancreatic islet D cells and in endocrine cells distributed throughout the mammalian gut, as well as in rare endocrine tumours (so-called somatostatinomas). The molecular forms appear to be co-packaged in dense-cored secretory granules, frequently with other transmitter substances. A recent paper has shown that the majority of somatostatin-containing axons in the rat spinal cord express vesicular gluatamate transporter protein-2 (VGLUT2).
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| Regulatory Status |
RUO – Research Use Only |
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