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Sodium butyrate

ALX-270-301

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HDAC inhibitor. Apoptosis inducer.

Short-chain fatty acid shown to be an inhibitor of histone deacetylases (HDACs). Induces apoptosis. Restores contextual memory in transgenic mouse model of Alzheimer’s. Induces pancreatic progenitor formation. Directs differentiation of mouse embryonic stem cells to hepatocytes with Cytokine Activin A. Sodium butyrate interferes with signal transduction processes, as well as, inhibits c-myc splicing.

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Product Details

Appearance	White to off-white solid.
CAS	156-54-7
Couple Target	HDAC
Couple Type	Inhibitor
Formula	C₄H₇O₂Na
MW	110.1
Purity	≥95% (HPLC)
RTECS	ET6400000
Solubility	Soluble in water (100mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Hygroscopic.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Inhibitors of histone deacetylases: correlation between isoform specificity and reactivation of HIV type 1 (HIV-1) from latently infected cells: K. Huber, et al.; J. Biol. Chem. 286, 22211 (2011), Abstract — Full Text
Effects of retinoic acid and sodium butyrate on gene expression, histone acetylation and inhibition of proliferation of melanoma cells: K. Demary, et al.; Cancer Lett. 163, 103 (2001), Abstract
Reduction of telomerase activity in human liver cancer cells by a histone deacetylase inhibitor: M. Nakamura, et al.; J. Cell Physiol. 187, 392 (2001), Abstract
Sodium Butyrate Induces Transcription from the Galpha i2 Gene Promoter through Multiple Sp1 Sites in the Promoter and by Activating the MEK- ERK Signal Transduction Pathway: J. Yang, et al.; J. Biol. Chem. 276, 25742 (2001), Abstract — Full Text
Apoptosis induced by the histone deacetylase inhibitor sodium butyrate in human leukemic lymphoblasts: D. Bernhard, et al.; FASEB J. 13, 1991 (1999), Abstract
Induction of the differentiated phenotype in human colon cancer cell is associated with the attenuation of subcellular tyrosine phosphorylation: B. Schwartz, et al.; Oncol. Res. 7, 277 (1995), Abstract
Sodium butyrate inhibits histone deacetylation in cultured cells: E.P. Candido, et al.; Cell 14, 105 (1978), Abstract

Related Products

Activin-A (human), (recombinant)

ALX-201-809

1 citation

Alternative Name	Inhibin β-1, FRP, FSH-releasing protein
Purity	≥95% (HPLC, Reducing and Non-reducing SDS-PAGE, UV spectroscopy at 280 nm)
Source	Produced in E. coli. Non-glycosylated homodimer, containing two 117 amino acid chains.

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Sodium butyrate

ALX-270-301

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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