SNC80

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δ-opioid receptor agonist

Highly selective and potent non-peptide δ−opioid receptor agonist.

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Appearance	White to off-white solid.
CAS	156727-74-1
Couple Target	Opioid receptor
Couple Type	Activator
Formula	C₂₈H₃₉N₃O₂
MW	449.6
Purity	≥98% (HPLC)
Solubility	Soluble in 100% ethanol, methanol, DMSO or dichloromethane.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Selectivity profiling of NOP, MOP, DOP and KOP receptor antagonists in the rat spinal nerve ligation model of mononeuropathic pain: K. Rutten, et al.; Eur. J. Pharmacol. 827, 41 (2018), Abstract
Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics: Schmid, C. L., Kennedy, N. M., et al.; Cell 171, 1165 (2017), Abstract
Structure-activity relationships for SNC80 and related compounds at cloned human delta and mu opioid receptors: R.J. Knapp , et al.; J. Pharmacol. Exp. Ther. 277, 1284 (1996), Abstract
SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist: E.J. Bilsky, et al.; J. Pharmacol. Exp. Ther. 273, 359 (1995), Abstract
Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4- [(alpha R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80): a highly selective, nonpeptide delta opioid receptor agonist: S.N. Calderon, et al.; J. Med. Chem. 37, 2125 (1994), Abstract

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